Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1

  • Ernő Zádor
  • Magdolna Kósa
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101795-1

Synonyms

Historical Background

The contraction and relaxation of skeletal muscle is regulated by the concomitant rise and fall of the cytoplasmic calcium level. The Ca2+ is released from the sarcoplasmic reticulum by ryanodine receptor and taken back to the SR by SERCA pumps. The idea of a relaxing factor had been put forward for a long time by many researchers seeking for control mechanism of muscle function. The successful candidate was found in a high-speed pellet of rabbit white skeletal muscle capable of hydrolyzing ATP in Ca2+- and Mg2+-dependent manner and requiring the presence of phospholipids. The dependence on phospholipids and incompatibility to detergents implicated that self-forming sealed vesicles accumulated calcium...

Keywords

Sarcoplasmic Reticulum Duchenne Muscular Dystrophy Brown Adipose Tissue Duchenne Muscular Dystrophy Myotonic Dystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgement

Thank you to C. Toyoshima for allowing to use images and legends of Fig. 1 from his review article (Toyoshima 2009).

References

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© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Institute of Biochemistry, Faculty of MedicineUniversity of SzegedSzegedHungary