Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

BEX3

  • Julhash U. Kazi
  • Nuzhat N. Kabir
  • Lars Rönnstrand
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101775-1

Synonyms

Historical Background

The Brain-Expressed X-linked (BEX) is a family of five proteins including BEX1, BEX2, BEX3, BEX4, and BEX5 (Kazi et al. 2015). BEX-family proteins are characterized by a highly conserved BEX domain (Fig. 1). Function of the BEX domain is still poorly understood. Recent studies identified a role of BEX domain containing proteins in growth control. All BEX genes cluster to the human Xq22 chromosome. BEX3 was the first BEX-family protein described and was initially named HGR74 (Rapp et al. 1990).

Keywords

PC12 Cell Nerve Growth Factor Nerve Growth Factor Receptor Ovarian Carcinoma Cell Line Human Ovarian Carcinoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Alvarez E, Zhou W, Witta SE, Freed CR. Characterization of the Bex gene family in humans, mice, and rats. Gene. 2005;357:18–28. doi:10.1016/j.gene.2005.05.012.CrossRefPubMedGoogle Scholar
  2. Calvo L, Anta B, Lopez-Benito S, Martin-Rodriguez C, Lee FS, Perez P, et al. Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. J Neurosci. 2015;35:7190–202. doi:10.1523/JNEUROSCI.4646-14.2015.CrossRefPubMedGoogle Scholar
  3. Descamps S, Toillon RA, Adriaenssens E, Pawlowski V, Cool SM, Nurcombe V, et al. Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways. J Biol Chem. 2001;276:17864–70. doi:10.1074/jbc.M010499200.CrossRefPubMedGoogle Scholar
  4. Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000;102:33–42.CrossRefPubMedGoogle Scholar
  5. Kazi JU, Kabir NN, Rönnstrand L. Brain-Expressed X-linked (BEX) proteins in human cancers. Biochim Biophys Acta. 2015;1856:226–33. doi:10.1016/j.bbcan.2015.09.001.PubMedGoogle Scholar
  6. Kim AJ, Lee CS, Schlessinger D. Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells. Gene. 2004;343:79–89. doi:10.1016/j.gene.2004.08.031.CrossRefPubMedGoogle Scholar
  7. Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, et al. 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction. J Biol Chem. 2001;276:17291–300. doi:10.1074/jbc.M005453200.CrossRefPubMedGoogle Scholar
  8. Lindblad O, Li T, Su X, Sun J, Kabir NN, Levander F, et al. BEX1 acts as a tumor suppressor in acute myeloid leukemia. Oncotarget. 2015;6(25):21395–405.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, et al. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem. 2000;275:17566–70. doi:10.1074/jbc.C000140200.CrossRefPubMedGoogle Scholar
  10. Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, et al. Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis. J Biol Chem. 2002;277:13973–82. doi:10.1074/jbc.M106342200.CrossRefPubMedGoogle Scholar
  11. Mukai J, Suvant P, Sato TA. Nerve growth factor-dependent regulation of NADE-induced apoptosis. Vitam Horm. 2003;66:385–402.CrossRefPubMedGoogle Scholar
  12. Park JA, Lee JY, Sato TA, Koh JY. Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat. J Neurosci. 2000;20:9096–103.PubMedGoogle Scholar
  13. Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, et al. Characterization of three abundant mRNAs from human ovarian granulosa cells. DNA Cell Biol. 1990;9:479–85.CrossRefPubMedGoogle Scholar
  14. Sano H, Mukai J, Monoo K, Close LG, Sato TA. Expression of p75NTR and its associated protein NADE in the rat cochlea. Laryngoscope. 2001;111:535–8. doi:10.1097/00005537-200103000-00027.CrossRefPubMedGoogle Scholar
  15. Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, et al. Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol. 2003;1:E74. doi:10.1371/journal.pbio.0000074.CrossRefPubMedPubMedCentralGoogle Scholar
  16. Tong X, Xie D, Roth W, Reed J, Koeffler HP. NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. Int J Oncol. 2003;22:1357–62.PubMedGoogle Scholar
  17. Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, et al. The TSC1 gene product hamartin interacts with NADE. Mol Cell Neurosci. 2007;35:100–8. doi:10.1016/j.mcn.2007.02.007.CrossRefPubMedGoogle Scholar
  18. Yoon K, Jang HD, Lee SY. Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. Biochem Biophys Res Commun. 2004;319:649–54. doi:10.1016/j.bbrc.2004.05.043.CrossRefPubMedGoogle Scholar
  19. Zhao J, Meyerkord CL, Du Y, Khuri FR, Fu H. 14-3-3 proteins as potential therapeutic targets. Semin Cell Dev Biol. 2011;22:705–12. doi:10.1016/j.semcdb.2011.09.012.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Julhash U. Kazi
    • 1
    • 2
  • Nuzhat N. Kabir
    • 2
  • Lars Rönnstrand
    • 1
  1. 1.Division of Translational Cancer Research, Department of Laboratory MedicineLund UniversityLundSweden
  2. 2.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh