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The Brain-Expressed X-linked (BEX) is a family of five proteins including BEX1, BEX2, BEX3, BEX4, and BEX5 (Kazi et al. 2015). BEX-family proteins are characterized by a highly conserved BEX domain (Fig. 1). Function of the BEX domain is still poorly understood. Recent studies identified a role of BEX domain containing proteins in growth control. All BEX genes cluster to the human Xq22 chromosome. BEX3 was the first BEX-family protein described and was initially named HGR74 (Rapp et al. 1990).
KeywordsPC12 Cell Nerve Growth Factor Nerve Growth Factor Receptor Ovarian Carcinoma Cell Line Human Ovarian Carcinoma Cell Line
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