Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

RASD1

Living reference work entry

Latest version View entry history

DOI: https://doi.org/10.1007/978-1-4614-6438-9_101764-2

Synonyms

Historical Background

DEXRAS1/RASD1/AGS1 was identified in three independent studies from 1998 to 2000. In 1998, Kemppainen and Behrend isolated a novel gene that was rapidly induced by the synthetic glucocorticoid, dexamethasone, in AtT-20 mouse pituitary tumor cells. They coined this new gene dexamethasone-inducible Ras protein 1 based on its homology to other members of the Ras superfamily of small GTPases (Kemppainen and Behrend 1998). A year later, Dexras1/Rasd1 was discovered in a yeast functional screen designed to identify mammalian genes that activate the pheromone response pathway in the absence of the pheromone receptor (Cismowski et al. 1999). It was given the name activator of G-protein signaling 1 (AGS1) based on its ability to activate G proteins in a G protein-coupled receptor (GPCR)-independent manner (Cismowski et al. 1999; Cismowski...

Keywords

Obesity Hydrolysis Dopamine Dexamethasone Glucocorticoid 
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References

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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  • Pascale Bouchard-Cannon
    • 1
    • 2
  • Hai-Ying Mary Cheng
    • 1
    • 2
  1. 1.Department of BiologyUniversity of Toronto MississaugaMississaugaCanada
  2. 2.Department of Cell and Systems BiologyUniversity of TorontoTorontoCanada