DEXRAS1/RASD1/AGS1 was identified in three independent studies from 1998 to 2000. In 1998, Kemppainen and Behrend isolated a novel gene that was rapidly induced by the synthetic glucocorticoid, dexamethasone, in AtT-20 mouse pituitary tumor cells. They coined this new gene dexamethasone-inducible Ras protein 1 based on its homology to other members of the Ras superfamily of small GTPases (Kemppainen and Behrend 1998). A year later, Dexras1/Rasd1 was discovered in a yeast functional screen designed to identify mammalian genes that activate the pheromone response pathway in the absence of the pheromone receptor (Cismowski et al. 1999). It was given the name activator of G-protein signaling 1 (AGS1) based on its ability to activate G proteins in a G protein-coupled receptor (GPCR)-independent manner (Cismowski et al. 1999; Cismowski...
KeywordsAtrial Natriuretic Factor Guanosine Diphosphate Glucocorticoid Responsive Element Pheromone Response Pathway White Adipose Tissue Mass
- Kim HJ, Cha JY, Seok JW, Choi Y, Yoon BK, Choi H, Yu JH, Song SJ, Kim A, Lee H, Kim D. Dexras1 links glucocorticoids to insulin-like growth factor-1 signaling in adipogenesis. Sci Rep. 2016;6Google Scholar
- Takahashi H, Umeda N, Tsutsumi Y, Fukumura R, Ohkaze H, Sujino M, van der Horst G, Yasui A, Inouye SI, Fujimori A, Ohhata T. Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus. Mol Brain Res. 2003;110(1):1–6.CrossRefPubMedGoogle Scholar
- Thapliyal A, Verma R, Kumar N. Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes. International journal of cell biology. 2014.Google Scholar