Historical Background
DEXRAS1/RASD1/AGS1 was identified in three independent studies from 1998 to 2000. In 1998, Kemppainen and Behrend isolated a novel gene that was rapidly induced by the synthetic glucocorticoid, dexamethasone, in AtT-20 mouse pituitary tumor cells. They coined this new gene dexamethasone-inducible Ras protein 1 based on its homology to other members of the Ras superfamily of small GTPases (Kemppainen and Behrend 1998). A year later, Dexras1/Rasd1 was discovered in a yeast functional screen designed to identify mammalian genes that activate the pheromone response pathway in the absence of the pheromone receptor (Cismowski et al. 1999). It was given the name activator of G-protein signaling 1 (AGS1) based on its ability to activate G proteins in a G protein-coupled receptor (GPCR)-independent manner (Cismowski et al. 1999; Cismowski...
Keywords
- Atrial Natriuretic Factor
- Guanosine Diphosphate
- Glucocorticoid Responsive Element
- Pheromone Response Pathway
- White Adipose Tissue Mass
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
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Bouchard-Cannon, P., Cheng, HY.M. (2016). RASD1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101764-1
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DOI: https://doi.org/10.1007/978-1-4614-6438-9_101764-1
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