Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

NDFIP1 and NDFIP2

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101705-1

Synonyms

Historical Background

Nedd4 family-interacting protein 1 (Ndfip1) was first identified in a far-western screen searching for proteins that interact with the WW domains of the Nedd4 ubiquitin ligase (Jolliffe et al. 2000). It was initially named Nedd4 WW domain-binding protein 5 (N4WBP5). Following this discovery, a closely related mammalian protein was identified (named N4WBP5A, now called Ndfip2) and further characterized as belonging to a small group of evolutionarily conserved proteins (Harvey et al. 2002), with a single homologue in yeast [Bsd2p (Hettema et al., 2004)] and Drosophila...

Keywords

Traumatic Brain Injury Ubiquitin Ligase Ubiquitous Expression Pattern Nedd4 Family Cell Survival Signaling Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Altin JA, Daley SR, Howitt J, Rickards HJ, Batkin AK, Horikawa K, et al. Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells. Proc Natl Acad Sci U S A. 2014;111(6):2067–74.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Beal AM, Ramos-Hernandez N, Riling CR, Nowelsky EA, Oliver PM. TGF-beta induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation. Nat Immunol. 2012;13(1):77–85.CrossRefGoogle Scholar
  3. Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y. Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells. Biochem Biophys Res Commun. 2015;465(4):851–6.CrossRefPubMedGoogle Scholar
  4. Dalton HE, Denton D, Foot NJ, Ho K, Mills K, Brou C, et al. Drosophila Ndfip is a novel regulator of Notch signaling. Cell Death Differ. 2011;18(7):1150–60.CrossRefPubMedGoogle Scholar
  5. Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang B, et al. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood. 2008;112(10):4268–75.CrossRefPubMedGoogle Scholar
  6. Foot NJ, Leong YA, Dorstyn LE, Dalton HE, Ho K, Zhao L, et al. Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. Blood. 2011;117(2):638–46.CrossRefPubMedGoogle Scholar
  7. Foot NJ, Gembus KM, Mackenzie K, Kumar S. Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver. Sci Rep. 2016;6:24045.CrossRefPubMedPubMedCentralGoogle Scholar
  8. Goh CP, Putz U, Howitt J, Low LH, Gunnersen J, Bye N, et al. Nuclear trafficking of Pten after brain injury leads to neuron survival not death. Exp Neurol. 2014;252:37–46.CrossRefPubMedGoogle Scholar
  9. Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem. 2002;277(11):9307–17.CrossRefPubMedGoogle Scholar
  10. Hettema EH, Valdez-Taubas J, Pelham HR. Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins. EMBO J. 2004;23(6):1279–88.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, et al. Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proc Natl Acad Sci U S A. 2009;106(36):15489–94.CrossRefPubMedPubMedCentralGoogle Scholar
  12. Howitt J, Lackovic J, Low LH, Naguib A, Macintyre A, Goh CP, et al. Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol. 2012;196(1):29–36.CrossRefPubMedPubMedCentralGoogle Scholar
  13. Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem J. 2000;351(3):557–65.CrossRefPubMedPubMedCentralGoogle Scholar
  14. Kang Y, Guo J, Yang T, Li W, Zhang S. Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips). Biochem J. 2015;472(1):71–82.CrossRefPubMedGoogle Scholar
  15. Liu XF, Culotta VC. Post-translation control of Nramp metal transport in yeast. Role of metal ions and the BSD2 gene. J Biol Chem. 1999;274(8):4863–8.CrossRefPubMedGoogle Scholar
  16. Mund T, Pelham HR. Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. EMBO Rep. 2009;10(5):501–7.CrossRefPubMedPubMedCentralGoogle Scholar
  17. Mund T, Pelham HR. Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. Proc Natl Acad Sci U S A. 2010;107(25):11429–34.CrossRefPubMedPubMedCentralGoogle Scholar
  18. Oliver PM, Cao X, Worthen GS, Shi P, Briones N, Macleod M, et al. Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity. 2006;25(6):929–40.CrossRefPubMedPubMedCentralGoogle Scholar
  19. Perry WL, Hustad CM, Swing DA, O’Sullivan TN, Jenkins NA, Copeland NG. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet. 1998;18(2):143–6.CrossRefPubMedGoogle Scholar
  20. Putz U, Howitt J, Doan A, Goh CP, Low LH, Silke J, et al. The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells. Sci Signal 2012;5(243):ra70.Google Scholar
  21. Ramos-Hernandez N, Ramon HE, Beal AM, Laroche A, Dekleva EA, Oliver PM. Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production. J Immunol. 2013;191(4):1536–46.CrossRefPubMedGoogle Scholar
  22. Sang Q, Kim MH, Kumar S, Bye N, Morganti-Kossman MC, Gunnersen J, et al. Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury. J Neurosci. 2006;26(27):7234–44.CrossRefPubMedGoogle Scholar
  23. Shearwin-Whyatt LM, Brown DL, Wylie FG, Stow JL, Kumar S. N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. J Cell Sci. 2004;117(16):3679–89.CrossRefPubMedGoogle Scholar
  24. Wang Y, Tong X, Ye X. Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation. J Immunol. 2012;189(11):5304–13.CrossRefPubMedGoogle Scholar
  25. Yip KH, Kolesnikoff N, Hauschild N, Biggs L, Lopez AF, Galli SJ, Kumar S, Grimbaldeston M. The Nedd4-2-Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation. Nat Commun. 2016;7:13198.Google Scholar

Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Centre for Cancer BiologyUniversity of South AustraliaAdelaideAustralia