Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Hypoxia-Inducible Factor-1

  • Tong Zhang
  • Zhaoji Liu
  • Zhaoyong Li
  • Huafeng Zhang
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101697-1

Synonyms

Historical Background

HIF-1, which is expressed in all metazoan organisms and serves as a transcriptional factor that responds to changes of available oxygen in the cellular environment, is a heterodimeric DNA-binding complex that is composed of two basic helix-loop-helix proteins of the PAS family: a constitutively expressed HIF-1β subunit (also known as the aryl hydrocarbon receptor nuclear translocator 1[ARNT1]) and a tightly regulated HIF-1α subunit (Wang et al. 1995). Hypoxia-inducible factor 1 (HIF-1) was first identified, biochemical purified, and molecular characterized by Gregg Semenza’s research group in the early 1990s (Semenza and Wang 1992). Both HIF-1α and HIF-1β are members of the bHLH-PAS superfamily proteins containing basic-helix-loop-helix (bHLH) and PER-ARNT-SIM (PAS) domains (Wang et al. 1995) (Fig. 1). HIF-1β subunit is a nonoxygen responsive protein, while the HIF-1α subunit is remarkably...

Keywords

Respiration Proline Pyruvate Integrin Imatinib 
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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Tong Zhang
    • 1
  • Zhaoji Liu
    • 1
  • Zhaoyong Li
    • 1
  • Huafeng Zhang
    • 1
  1. 1.Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic DiseaseInnovation Center for Cell Signaling Network, and School of Life Sciences, University of Science and Technology of ChinaHefeiChina