Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

IL-1 Receptor Family

  • Diana Boraschi
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101687-1

Synonyms

Historical Background

The family of IL-1 receptors (IL-1R) belongs to the large superfamily of TIR domain-containing receptors, key molecules of innate immunity, which is the fast and non-specific type of immune response to pathogens and other stressful events (Boraschi and Tagliabue 2013; Dinarello 2013). The TIR superfamily encompasses Toll-like receptors (TLR), which are the main sensors of exogenous molecules (in general microbial components) and the IL-1R family, which bind endogenous inflammation-related cytokines.

The two families differ in their extracellular ligand-binding domains, which are different and specific for groups of ligands, with the IL-1R family being immunoglobulin (Ig) domain-bearing receptors, while the TLR family encompasses receptors with a leucine-rich repeat (LRR) domain. On the other hand, receptors of the TIR superfamily are characterized by the presence of a common sequence, the Toll-IL-1 Receptor (TIR) domain, in...

Keywords

Soluble Form Plasma Membrane Receptor Receptor Chain Trimeric Complex Initiate Signal Transduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Booker CS, Grattan DR. Identification of a truncated splice variant of IL-18 receptor alpha in the human and rat, with evidence of wider evolutionary conservation. PeerJ. 2014;2:e560.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Booker CS, Grattan DR. IL1R9 is evolutionarily related to IL18BP and may function as an IL-18 receptor. J Immunol. 2017;198:270–8.Google Scholar
  3. Bonecchi R, Garlanda C, Mantovani A, Riva F. Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation. Cytokine. 2016;87:37–45.Google Scholar
  4. Boraschi D, Tagliabue A. The interleukin-1 receptor family. Semin Immunol. 2013;25:394–407.CrossRefPubMedGoogle Scholar
  5. Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME, Garlanda C, Mantovani A, O’Neill LAJ. IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J Neurochem. 2008;105:1960–9.Google Scholar
  6. Dinarello CA. Overview of the IL-1 family of ligands and receptors. Semin Immunol. 2013;25:389–93.CrossRefPubMedGoogle Scholar
  7. Garlanda C, Riva F, Bonavita E, Mantovani A. Negative regulatory receptors of the IL-1 family. Semin Immunol. 2013;25:408–15.CrossRefPubMedGoogle Scholar
  8. Gosselin D, Belalvance M-A, Rivest S. IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term servival following excitotoxic insults. Front Immunol. 2013;7:9.Google Scholar
  9. Martin MU. IL-33 and the IL-33 receptor complex. Semin Immunol. 2013;25:449–57.CrossRefPubMedGoogle Scholar
  10. Martin NT, Martin MU. Interleukin 33 is a guardian of barriers and a local alarmin. Nat Immunol. 2016;17:122–31.CrossRefPubMedGoogle Scholar
  11. Molgora M, Barajon I, Mantovani A, Garlanda C. Regulatory role of IL-1R8 in immunity and disease. Front Immunol. 2016;7:149.CrossRefPubMedPubMedCentralGoogle Scholar
  12. Mora J, Schlemmer A, Wittig I, Richter F, Putyrski M, Frank A-C, et al. Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol. 2016;8:426–38.CrossRefGoogle Scholar
  13. Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, et al. IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol. 2015;16:354–65.CrossRefPubMedGoogle Scholar
  14. Nold-Petry CA, Nold MF, Nielsen JW, Bustamante A, Zepp JA, Storm KA, et al. Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling. J Biol Chem. 2009;284:25900–11.CrossRefPubMedPubMedCentralGoogle Scholar
  15. Novick D, Kim S, Kaplanski G, Dinarello CA. Interleukin-18, more than a Th1 cytokine. Semin Immunol. 2013;25:439–48.CrossRefPubMedGoogle Scholar
  16. Peters VA, Joesting JJ, Freund GG. IL-1 receptor 2 (IL-1R2) and its role in immune regulation. Brain Behav Immun. 2013;32:1–8.CrossRefPubMedGoogle Scholar
  17. Takei S, Hoshino T, Matsunaga K, Sakazaki Y, Sawada M, Oda H, et al. Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis. Arthritis Res Ther. 2011;13:R52.CrossRefPubMedPubMedCentralGoogle Scholar
  18. Thomas C, Bazan JF, Garcia KC. Structure of the activating IL-1 receptor signaling complex. Nat Struct Mol Biol. 2012;19:455–7.CrossRefPubMedPubMedCentralGoogle Scholar
  19. Towne JE, Garka KE, Renshaw BR, Virca GD, Sims JE. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-κB and MAPKs. J Biol Chem. 2004;279:13677–88.CrossRefPubMedGoogle Scholar
  20. van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, et al. IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc Natl Acad Sci U S A. 2012;109:3001–5.CrossRefPubMedPubMedCentralGoogle Scholar
  21. Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J Biol Chem. 1997;272:7727–31.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Institute of Protein BiochemistryNational Research CouncilNaplesItaly