IL-1 Receptor Family
The family of IL-1 receptors (IL-1R) belongs to the large superfamily of TIR domain-containing receptors, key molecules of innate immunity, which is the fast and non-specific type of immune response to pathogens and other stressful events (Boraschi and Tagliabue 2013; Dinarello 2013). The TIR superfamily encompasses Toll-like receptors (TLR), which are the main sensors of exogenous molecules (in general microbial components) and the IL-1R family, which bind endogenous inflammation-related cytokines.
The two families differ in their extracellular ligand-binding domains, which are different and specific for groups of ligands, with the IL-1R family being immunoglobulin (Ig) domain-bearing receptors, while the TLR family encompasses receptors with a leucine-rich repeat (LRR) domain. On the other hand, receptors of the TIR superfamily are characterized by the presence of a common sequence, the Toll-IL-1 Receptor (TIR) domain, in...
KeywordsSoluble Form Plasma Membrane Receptor Receptor Chain Trimeric Complex Initiate Signal Transduction
- Booker CS, Grattan DR. IL1R9 is evolutionarily related to IL18BP and may function as an IL-18 receptor. J Immunol. 2017;198:270–8.Google Scholar
- Bonecchi R, Garlanda C, Mantovani A, Riva F. Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation. Cytokine. 2016;87:37–45.Google Scholar
- Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME, Garlanda C, Mantovani A, O’Neill LAJ. IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J Neurochem. 2008;105:1960–9.Google Scholar
- Gosselin D, Belalvance M-A, Rivest S. IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term servival following excitotoxic insults. Front Immunol. 2013;7:9.Google Scholar
- Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J Biol Chem. 1997;272:7727–31.CrossRefPubMedGoogle Scholar