Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

PITX2 (Pituitary Homeobox Gene 2)

  • Diego Franco
  • Amelia Aranega
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101670-1

Synonyms

Historical Background

PITX2 belongs to the bicoid class of homeodomain transcription factors, which play essential roles in embryonic development and disease. Pioneered evidences reported by Semina et al. (1996) identified 4q25 translocations association with Rieger syndrome, a human pathological condition characterized by underdevelopment of the teeth, mild craniofacial abnormalities, and distinct eye defects, especially glaucoma. These authors isolated an mRNA transcript with a predicted 271-amino acid protein and named it as RIEG gene. RIEG showed high homology with the PITX1 protein, differing by only two residues, and thus was later dubbed PITX2. Soon thereafter, Gage and Camper (1997) identified PITX2 (RIEG) gene in an adult mouse pituitary gland screen for novel homeobox genes and reported two alternatively spliced mRNA products, namely, PITX2A and PITX2B. Soon thereafter, using a differential display method, Arakawa et al. (1998)...

Keywords

Homeobox Transcription Factor PITX2 Expression Atrial Isomerism Ocular Development Cardiac Looping 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Authors and Affiliations

  1. 1.Department of Experimental BiologyUniversity of JaénJaénSpain