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Encyclopedia of Signaling Molecules pp 1–5Cite as

DPP8

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Synonyms

Dipeptidyl peptidase 8; Dipeptidyl peptidase-related protein 1; DP8; DPP8; DPRP1

Historical Background

Dipeptidyl peptidase (DPP) 8 is a member of the DPP4/DPP-IV gene and enzyme family, which belongs to clan SC of serine proteases, family S9, subfamily S9B. S9B proteases have a unique ability to remove Xaa-Pro dipeptides from the N-terminus of substrates. Fibroblast activation protein (FAP), DPP4, DPP8, and DPP9 are the S9B peptidases. Several extensive reviews provide detail (Zhang et al. 2013; Waumans et al. 2015; Klemann et al. 2016; Wilson et al. 2016).

DPP8 has been localized to human chromosome 15q22.32 (Abbott et al. 2000) and 9:65032458 in the mouse. The human DPP8 gene spans 71 kb and comprises 20 exons (Abbott et al. 2000), which is shorter and with fewer exons than DPP4 but encodes more amino acids (882 versus 766 residues). In DPP8 and DPP9, the gene sequence encoding the catalytic serine and its nearby highly conserved amino acids is in a single exon, whereas in...

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References

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Acknowledgments

MDG is supported by grants 1105238 and 1113842 from the Australian National Health and Medical Research Council.

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Authors and Affiliations

  1. Centenary Institute and Sydney Medical School, The University of Sydney, Locked Bag No. 6, 2042, Newtown, NSW, Australia

    Mark D. Gorrell & Hui Emma Zhang

Authors
  1. Mark D. Gorrell
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  2. Hui Emma Zhang
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Correspondence to Mark D. Gorrell .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Gorrell, M.D., Zhang, H.E. (2016). DPP8. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101654-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101654-1

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  • Online ISBN: 978-1-4614-6438-9

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