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HLA Class I Histocompatibility Antigen, Alpha Chain E

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 65 Accesses

Synonyms

EA1.2; EA2.1; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; HLA-6.2; HLAE; HLA-E; Human leukocyte antigen E; Lymphocyte antigen; Major histocompatibility complex E; Major histocompatibility complex, class I, E; MHC; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; QA1

Historical Background

Historically, the gene cluster on chromosome 6 that harbors the human leukocyte antigen (HLA) system was termed major histocompatibility complex (MHC), because their discovery was linked to experiments regarding tissue transplantations. It became later apparent that the HLA system is comprised of several molecule classes of which the HLA class I and HLA class II molecules are surface-expressed glycoproteins that present peptides of self or pathogenic origin to different T cell subtypes. This procedure termed MHC restriction sheds new light on T cell–mediated immunity and also elucidates the obstacle of organ...

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Authors and Affiliations

  1. Institute for Transfusion Medicine, Hannover Medical School, Medical Park, Feodor-Lynen-Straße 5, 30625, Hannover, Germany

    Alexander A. Celik, Rainer Blasczyk & Christina Bade-Döding

Authors
  1. Alexander A. Celik
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  2. Rainer Blasczyk
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  3. Christina Bade-Döding
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Corresponding author

Correspondence to Christina Bade-Döding .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Celik, A.A., Blasczyk, R., Bade-Döding, C. (2016). HLA Class I Histocompatibility Antigen, Alpha Chain E. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101650-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101650-1

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  • Online ISBN: 978-1-4614-6438-9

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