Skip to main content
SpringerLink
Log in
Book cover

Encyclopedia of Signaling Molecules pp 1–6Cite as

Histone H3

  • Living reference work entry
  • First Online:

  • 289 Accesses

Synonyms

H3 histone family, member A; H3/A; H31; H3FA; H3FB; H3FC; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; histone 1, H3a; histone cluster 1, H3a; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l

H3 histone family, member M; H3 histone, family 2; histone 2, H3c; histone H3.2; histone H3/m; histone H3/o

H3 histone, family 3A; H3 histone, family 3B (H3.3B); H3.3A; H3.3B; H33; H3F3; H3F3A; H3F3B; Histone H3.3

Historical Background

The eukaryotic genome is extraordinarily well organized. This is achieved through the winding of DNA to form continuous arrays of nucleosome, the fundamental repeating unit of chromatin. Each nucleosome consists of ~147 base pairs of DNA wrapped around a core histone octamer (two copies each of histone H2A, H2B, H3, and H4). Based on this, by the association...

This is a preview of subscription content, log in via an institution.

References

  • Bannister AJ, Kouzarides T. Reversing histone methylation. Nature. 2005;436:1103–6.

    Article  CAS  PubMed  Google Scholar 

  • Britton LM, Newhart A, Bhanu NV, Sridharan R, Gonzales-Cope M, Plath K, et al. Initial characterization of histone H3 serine 10 O-acetylation. Epigenetics. 2013;8:1101–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen Y, Sprung R, Tang Y, Ball H, Sangras B, Kim SC, et al. Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics. 2007;6:812–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dai L, Peng C, Montellier E, Lu Z, Chen Y, Ishii H, et al. Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. Nat Chem Biol. 2014;10:365–70.

    Article  CAS  PubMed  Google Scholar 

  • Fong JJ, Nguyen BL, Bridger R, Medrano EE, Wells L, Pan S, Sifers RN. β-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3. J Biol Chem. 2012;287:12195–203.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • García-Giménez JL, Òlaso G, Hake SB, Bönisch C, Wiedemann SM, Markovic J, et al. Histone H3. glutathionylation in proliferating mammalian cells destabilizes nucleosomal structure. Antioxid Redox Signal. 2013;19:1305–20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hinchcliffe EH, Day CA, Karanjeet KB, Fadness S, Langfald A, Vaughan KT, Dong Z. Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation. Nat Cell Biol. 2016;18:668–75.

    Article  CAS  PubMed  Google Scholar 

  • Holliday R. Epigenetics: a historical overview. Epigenetics. 2006;1:76–80.

    Article  PubMed  Google Scholar 

  • Jiang T, Zhou X, Taghizadeh K, Dong M, Dedon PC. N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage. Proc Natl Acad Sci USA. 2007;104:60–5.

    Article  CAS  PubMed  Google Scholar 

  • Kallappagoudar S, Yadav RK, Lowe BR, Partridge JF. Histone H3 mutations--a special role for H3.3 in tumorigenesis? Chromosoma. 2015;124:177–89.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kothapalli N, Camporeale G, Kueh A, Chew YC, Oommen AM, Griffin JB, Zempleni J. Biological functions of biotinylated histones. J Nutr Biochem. 2005;16:446–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kouzarides T. Chromatin modifications and their function. Cell. 2007;128:693–705.

    Article  CAS  PubMed  Google Scholar 

  • Maze I, Noh KM, Soshnev AA, Allis CD. Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Nat Rev Genet. 2014;15:259–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Monks TJ, Xie R, Tikoo K, Lau SS. Ros-induced histone modifications and their role in cell survival and cell death. Drug Metab Rev. 2006;38:755–67.

    Article  CAS  PubMed  Google Scholar 

  • Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, et al. Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation. Mol Cell. 2015;58:203–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 1998;12:599–606.

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Zhai L, Xu J, Joo HY, Jackson S, Erdjument-Bromage H, et al. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell. 2006;22:383–94.

    Article  PubMed  Google Scholar 

  • Xie Z, Dai J, Dai L, Tan M, Cheng Z, Wu Y, et al. Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics. 2012;11:100–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, et al. Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation. Mol Cell. 2016;62:194–206.

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev. 2001;15:2343–60.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, 515041, People’s Republic of China

    Yan-Ming Xu, Yue Yao & Andy T. Y. Lau

Authors
  1. Yan-Ming Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yue Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andy T. Y. Lau
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andy T. Y. Lau .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Xu, YM., Yao, Y., Lau, A.T.Y. (2016). Histone H3. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101644-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101644-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation