Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Glypicans (GPCs)

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101637-1

Synonyms

Glypican-1: Glypican; Glypican 1; Glypican-1; GPC1

Glypican-2: Glypican 2; Glypican-2; GPC2; Cerebroglycan

Glypican-3: Glypican 3; Glypican-3; GPC3; MXR7; OCI-5

Glypican-4: Glypican 4; Glypican-4; GPC4; K-glypican

Glypican-5: Glypican 5; Glypican-5; GPC5

Glypican-6: Glypican 6; Glypican-6; GPC6

Historical Background

Glypican-3 (GPC3) is the first glypican that was cloned (Filmus et al. 1988). Initially named OCI-5, GPC3 was identified in 1988 as a gene whose expression was developmentally regulated in the intestine. Two years later, the cloning of Glypican-1 (GPC1) was reported. This report characterized GPC1 as a glycosylphosphatidylinositol (GPI)-anchored heparan sulfate proteoglycan (HSPG), but it did not indicate that GPC1 displays significantly homology with GPC3 (David et al. 1990). This homology was noticed 4 years later in a study that reported the cloning of Glypican-2 (initially called cerebroglycan) (Stipp et al. 1994). This study established for the first time the...

Keywords

Pancreatic Cancer Esophageal Squamous Cell Carcinoma Nephrotic Syndrome Primary Cilium Cleft Palate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Sunnybrook Research InstituteUniversity of TorontoTorontoCanada