Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Glypicans (GPCs)

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101637-1


Glypican-1: Glypican; Glypican 1; Glypican-1; GPC1

Glypican-2: Glypican 2; Glypican-2; GPC2; Cerebroglycan

Glypican-3: Glypican 3; Glypican-3; GPC3; MXR7; OCI-5

Glypican-4: Glypican 4; Glypican-4; GPC4; K-glypican

Glypican-5: Glypican 5; Glypican-5; GPC5

Glypican-6: Glypican 6; Glypican-6; GPC6

Historical Background

Glypican-3 (GPC3) is the first glypican that was cloned (Filmus et al. 1988). Initially named OCI-5, GPC3 was identified in 1988 as a gene whose expression was developmentally regulated in the intestine. Two years later, the cloning of Glypican-1 (GPC1) was reported. This report characterized GPC1 as a glycosylphosphatidylinositol (GPI)-anchored heparan sulfate proteoglycan (HSPG), but it did not indicate that GPC1 displays significantly homology with GPC3 (David et al. 1990). This homology was noticed 4 years later in a study that reported the cloning of Glypican-2 (initially called cerebroglycan) (Stipp et al. 1994). This study established for the first time the...


Pancreatic Cancer Esophageal Squamous Cell Carcinoma Nephrotic Syndrome Primary Cilium Cleft Palate 
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Sunnybrook Research InstituteUniversity of TorontoTorontoCanada