Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

GTP-Binding Protein Rheb

  • Jeffrey J. Heard
  • Fuyuhiko Tamanoi
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101614-1


Historical Background

Ras homolog enriched in brain (Rheb) plays a significant role in regulating protein synthesis, cell growth, cell cycle, and autophagy (Aspuria and Tamanoi 2004; Heard et al. 2014). Deregulation of Rheb signaling has been shown to cause diseases ranging from developmental disorders to cancer. Rheb was initially discovered as a protein sharing strong homology with Ras and whose expression was rapidly induced in brain neuronal cell by increased synaptic activity (Yamagata et al. 1994). Since then, Rheb has been shown to be widely expressed and to be conserved in eukaryotes from yeast to human. Higher eukaryotes express two Rheb proteins, Rheb1 and Rheb2 (RhebL1). Two separate genes encode these proteins that share 74% similarity. Their functions appear similar, but their tissue expression profiles differ significantly. Rheb is a member of the Ras superfamily of GTP-binding proteins that act as molecular switches in the cell to activate...


Tuberous Sclerosis Tuberous Sclerosis Complex Carbamoyl Phosphate mTORC1 Signaling TSC2 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of Microbiology, Immunology & Molecular GeneticsUniversity of CaliforniaLos AngelesUSA
  2. 2.Molecular Biology Institute, University of CaliforniaLos AngelesUSA