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Encyclopedia of Signaling Molecules pp 1–6Cite as

FAP

  • Living reference work entry
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Synonyms

Fibroblast activation protein; Fibroblast activation protein alpha; Seprase; FAP

Historical Background

Fibroblast activation protein (FAP; FAP-α; seprase) is a type II 95 kDa post-proline cleaving atypical serine protease, closely related to the dipeptidyl peptidases (DPP) DPP-4, DPP-8, and DPP-9 in the prolyl oligopeptidase gene and enzyme family. FAP is conserved throughout chordate evolution, with homologs in human (hFAP), mouse (mFAP), and Xenopus laevis (89 % and 50 % protein sequence identity to hFAP, respectively). FAP expression correlates with tissue remodeling events (Hamson et al. 2014; Liu et al. 2015; Jiang et al. 2016). FAP is also phylogenetically linked to the prototype prolyl oligopeptidase, which is prolyl endopeptidase (PEP; PREP). FAP has both an endopeptidase activity that is similar to but distinct from that of PEP and a DPP activity that is similar to those of DPP4, DPP8, and DPP9 as well as the unrelated peptidase DPP7 (DPP-II).

FAP was originally...

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References

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Acknowledgment

MDG is supported by grants 1105238 and 1113842 from the Australian National Health and Medical Research Council.

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Authors and Affiliations

  1. Centenary Institute and Sydney Medical School, The University of Sydney, Locked Bag No. 6, Newtown, NSW, 2042, Australia

    Natasa Polak & Mark D. Gorrell

Authors
  1. Natasa Polak
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  2. Mark D. Gorrell
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Corresponding author

Correspondence to Mark D. Gorrell .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Polak, N., Gorrell, M.D. (2016). FAP. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101596-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101596-1

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  • Online ISBN: 978-1-4614-6438-9

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