Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Parkin

  • Fabienne C. Fiesel
  • Thomas R. Caulfield
  • Owen A. Ross
  • Wolfdieter Springer
Living reference work entry

Latest version View entry history

DOI: https://doi.org/10.1007/978-1-4614-6438-9_101588-2

Synonyms

Historical Background

Mutations in the PARKIN gene (chromosome 6q25–27) were first identified in 1998 as a cause for autosomal-recessive juvenile parkinsonism (AR-JP) (Kitada et al. 1998). By now hundreds of PARKIN mutations including single amino acid changes and deletions/duplications have been identified and account for more than 50% of cases with familial recessive Parkinson’s disease (PD) (Corti et al. 2011). In addition to their causative role in PD, mutations in PARKIN have also been found in numerous cancer tissues and a tumor suppressive role has been described for the protein (Xu et al. 2014). PARKINis located on chromosome 6 and is one of the largest genes in the human genome spanning...

Keywords

Parkin Mutation Mitochondrial Quality Control Parkin Function Flexible Linker Region Lysine Linkage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  • Fabienne C. Fiesel
    • 1
  • Thomas R. Caulfield
    • 1
  • Owen A. Ross
    • 1
  • Wolfdieter Springer
    • 1
  1. 1.Department of NeuroscienceMayo Clinic, Mayo Clinic Graduate School of Biomedical SciencesJacksonvilleUSA