Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Dystroglycan

  • Valérie Bello
  • Thierry Darribère
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101578-1

Synonyms

Historical Background

Thirty years ago, the biochemical studies of plasma membranes of rodent NG108–15 neural hybrid cells, 14-day embryonic chicken brain, and mouse 3 T3 fibroblasts had led to the identification of cranin (LBP120), a glycosylated laminin-binding protein. Later, by sucrose-gradient centrifugation following purification of proteins from heavy microsomes of rabbit skeletal muscles using wheat germ agglutinin and DEAE-sepharose, four novel glycoproteins associated with dystrophin were purified and labelled as the “dystrophin-glycoprotein complex (DGC)” (Ervasti et al. 1990). At the center of this complex, the dystroglycan (DG) has been identified as a glycan component whose amino acid sequence is identical to cranin. Since then, other members of the DGC were identified. Thus, the DGC provides a link between proteins of the extracellular...

Keywords

Muscular Dystrophy Glycan Structure Notochord Cell Congenital Muscular Dystrophy Mycobacterium Leprae 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Sorbonne Universités, UPMC Univ. Paris 06, CNRSLaboratoire de Biologie du Développement, Institut de Biologie Paris Seine (LBD – IBPS)ParisFrance