Synonyms
Historical Background
In 1998 the De Camilli Lab (Yale University) isolated a novel protein able to bind the endocytic protein eps15 from rat brain extracts and accordingly named it as Eps15 interacting protein 1, Epsin-1 or just Epn1 (Fig. 1 and Chen et al. 1998). Conservation of Epn1 was evident as sequence comparison revealed homology to the mitotic phosphoprotein-90 from Xenopus laevis and to the Ent1 and Ent2 yeast proteins. The Epn1 paralog, Epn2, was also discovered by the De Camilli Lab the following year (Rosenthal et al. 1999) which along with Epn1 was found localized at the plasma membrane and to participate in clathrin-mediated endocytosis (Sen et al. 2012; Wendland 2002). While these Epn paralogs showed widespread expression with substantial enrichment in the brain, a later described third paralog named epsin-3 was found to be virtually restricted to keratinocytes, gastric parietal cells, and several carcinomas (Sen et al. 2012).
Keywords
- Epidermal Growth Factor Receptor
- Notch Signaling
- Notch Ligand
- Epithelial Sodium Channel
- Endocytic Protein
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
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Aguilar, R.C. (2016). Epsin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101568-1
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DOI: https://doi.org/10.1007/978-1-4614-6438-9_101568-1
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