Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Type-1 Cannabinoid Receptor

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101565-1

Synonyms

Historical Background

The use of cannabis (Cannabis sativa) has been known for centuries, but it was necessary to wait until the late 1980s to understand the molecular basis responsible for its medical and recreational properties. Unlike cocaine and morphine, isolated as crystalline salts from coca leaves and opium respectively, the active constituent of cannabis appeared as an oily extract, difficult to isolate in pure form. Only in the 1960s isolation, characterization, and chemical synthesis of the active cannabis constituent, Δ9-tetrahydrocannabinol (THC), was possible. The identification of THC allowed a reevaluation of cannabis pharmacology and gradually boosted research towards the understanding of the molecular and cellular mechanisms underlying its therapeutic efficacy.

Although the existence of THC-binding cannabinoid receptors, and of an even more surprising ensamble of metabolic enzymes and transporters...

Keywords

Irritable Bowel Syndrome Anorexia Nervosa Bulimia Nervosa Heteromeric Complex Cannabis Dependence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Endocannabinoid Research GroupInstitute of Biomolecular Chemistry, National Research CouncilPozzuoliItaly
  2. 2.Department of MedicineCampus Bio-Medico University of RomeRomeItaly
  3. 3.European Center for Brain Research/IRCCS Santa Lucia FoundationRomeItaly