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Encyclopedia of Signaling Molecules pp 1–6Cite as

Cyclin B

  • Living reference work entry
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Synonyms and Variants

G2/Mitotic-specific cyclin B

Homo sapiens

Cyclin B1:

protein: G2/mitotic-specific cyclin-B1

gene: CCNB1

locus: Chr. 5 q12

sequence: http://www.uniprot.org/blast/?about=P14635-1

Cyclin B2:

protein: G2/mitotic-specific cyclin-B2

gene: CCNB2

locus: Chr. 15 q21.3

sequence: http://www.uniprot.org/uniparc/UPI00001275B3

Cyclin B3:

protein: G2/mitotic-specific cyclin-B3

gene: CCNB3

locus: Chr. X p11

sequence: http://www.uniprot.org/uniparc/UPI000022DC76

Mus musculus

Cyclin B1, cyclin B2, cyclin B3

Arabidopsis thaliana

proteins: Cyclin B1-1, Cyclin B1-2, Cyclin B1-3, Cyclin B1-4, Cyclin B1-5, Cyclin B2-1, Cyclin B2-2, Cyclin B2-3, Cyclin B2-4, Cyclin B2-5, Cyclin B3-1 (putative)

genes: CYCB1-1, CYCB1-2, CYCB1-3, CYCB1-4, CYCB1-5, CYCB2-1, CYCB2-2, CYCB2-3, CYCB2-4, CYCB2-5, CYCB3-1 (putative)

Caenorhabditis elegans

proteins: Cyclin B1, Cyclin B3

genes: cyb-1, cyb-3

Schizosaccharomyces pombe

proteins: cyclin cig2, cyclin cdc13

genes: cig2, cdc13

Historical Background

Mitotic...

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References

  • Charrier-Savournin FB, Château MT, Gire V, Sedivy J, Piette J, Dulic V. p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. Mol Biol Cell. 2004;15(9):3965–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chesnel F, Bazile F, Pascal A, Kubiak JZ. Cyclin B dissociation from CDK1 precedes its degradation upon MPF inactivation in mitotic extracts of Xenopus laevis embryos. Cell Cycle. 2007a;5(15):1687–98.

    Article  Google Scholar 

  • Chesnel F, Bazile F, Pascal A, Kubiak JZ. Cyclin B2/cyclin-dependent kinase1 dissociation precedes CDK1 Thr-161 dephosphorylation upon M-phase promoting factor inactivation in Xenopus laevis cell-free extract. Int J Dev Biol. 2007b;51(4):297–305.

    Article  CAS  PubMed  Google Scholar 

  • El Dika M, Laskowska-Kaszub K, Koryto M, Dudka D, Prigent C, Tassan JP, Kloc M, Polanski Z, Borsuk E, Kubiak JZ. CDC6 controls dynamics of the first embryonic M-phase entry and progression via CDK1 inhibition. Dev Biol. 2014;396(1):67–80.

    Article  CAS  PubMed  Google Scholar 

  • Evans T, Rosenthal ET, Youngblom J, Distel D, Hunt T. Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell. 1983;33(2):389–96.

    Article  CAS  PubMed  Google Scholar 

  • Gautier J, Norbury C, Lohka M, Nurse P, Maller J. Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. Cell. 1988;54(3):433–9.

    Article  CAS  PubMed  Google Scholar 

  • Gautier J, Minshull J, Lohka M, Glotzer M, Hunt T, Maller JL. Cyclin is a component of maturation-promoting factor from Xenopus. Cell. 1990;60(3):487–94.

    Article  CAS  PubMed  Google Scholar 

  • Gopinathan L, Ratnacaram CK, Kaldis P. Established and novel Cdk/cyclin complexes regulating the cell cycle and development. Results Probl Cell Differ. 2011;53:365–89.

    Article  CAS  PubMed  Google Scholar 

  • Hara M, Abe Y, Tanaka T, Yamamoto T, Okumura E, Kishimoto T. Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor. Nat Commun. 2012;3:1059.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hassan KA, El-Naggar AK, Soria JC, Liu D, Hong WK, Mao L. Clinical significance of cyclin B1 protein expression in squamous cell carcinoma of the tongue. Clin Cancer Res. 2001;7(8):2458–62.

    CAS  PubMed  Google Scholar 

  • Kreis NN, Sanhaji M, Krämer A, Sommer K, Rödel F, Strebhardt K, Yuan J. Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells. Oncogene. 2010;29(41):5591–603.

    Article  CAS  PubMed  Google Scholar 

  • Masui Y, Markert CL. Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes. J Exp Zool. 1971;177(2):129–45.

    Article  CAS  PubMed  Google Scholar 

  • Murray AW, Kirschner MW. Cyclin synthesis drives the early embryonic cell cycle. Nature. 1989;339(6222):275–80.

    Article  CAS  PubMed  Google Scholar 

  • Nigam N, Prasad S, George J, Shukla Y. Lupeol induces p53 and cyclin-B-mediated G2/M arrest and targets apoptosis through activation of caspase in mouse skin. Biochem Biophys Res Commun. 2009;381(2):253–8.

    Article  CAS  PubMed  Google Scholar 

  • Nishiyama A, Tachibana K, Igarashi Y, Yasuda H, Tanahashi N, Tanaka K, Ohsumi K, Kishimoto T. A nonproteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phase. Genes Dev. 2000;14(18):2344–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Verde F, Dogterom M, Stelzer E, Karsenti E, Leibler S. Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts. J Cell Biol. 1992;118(5):1097–108.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. CNRS, UMR 6290, Institute of Genetics and Development of Rennes, Cell Cycle Group, F-35043, Rennes, France

    Jacek Kubiak & Mikolaj Cup

  2. University Rennes 1, UEB, IFR 140, Faculty of Medicine, F-35043, Rennes, France

    Jacek Kubiak & Mikolaj Cup

  3. Laboratory of Regenerative Medicine, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland

    Jacek Kubiak, Mikolaj Cup & Jakub Janiec

  4. The Houston Methodist Research Institute, Houston, TX, USA

    Malgorzata Kloc

  5. Department of Surgery, The Houston Methodist Hospital, Houston, TX, USA

    Malgorzata Kloc

  6. University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Malgorzata Kloc

Authors
  1. Jacek Kubiak
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  2. Mikolaj Cup
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  3. Jakub Janiec
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  4. Malgorzata Kloc
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Corresponding author

Correspondence to Jacek Kubiak .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Kubiak, J., Cup, M., Janiec, J., Kloc, M. (2016). Cyclin B. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101558-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101558-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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