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CDK5

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

CDK5; Cyclin-dependent kinase 5; NCLK; Neuronal CDC2-like kinase; AW048668; Crk6; CDC2-related kinase 6; PSSALRE kinase

Historical Background

Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine-protein kinase, was originally purified from bovine brain and defined as a neuronal CDC2 (CDK1)-like kinase (NCLK) (Roder and Ingram 1991; Hellmich et al. 1992). Later on, CDK5 demonstrated capability to induce the Alzheimer-like characteristics by phosphorylation of tau protein (Baumann et al. 1993). p35 (CDK5R1) was then characterized as a regulatory subunit of CDK5 to activate its kinase activity, with subsequent identification of its isoform p39 (CDK5R2) (Tsai et al. 1994; Tang et al. 1995). CDK5/p35 is the first example of a CDC2-like kinase with neuronal function. A truncated form of p35, p25, was purified with CDK5 as a hetero-dimer exhibiting activity in vitro and regarded as a novel regulatory subunit of CDK5 (Lew et al. 1994). Accumulation of p25 is found in...

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  1. State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China

    Yumeng Guo, Yu Wang & Bo Bai

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  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Guo, Y., Wang, Y., Bai, B. (2016). CDK5. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101554-1

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