Related Molecules in the Encyclopedia
Bub1 was originally discovered as a gene required for cell cycle arrest during mitosis in response to the microtubule depolymerizing drug benzimidazole in the model organism Saccharomyces cerevisiae (Hoyt et al. 1991). Mutant yeast were unable to arrest and inhibit the budding process at the end of mitosis, a marker for cell cycle progression, hence the name Budding Uninhibited by Benzimidazole 1 (BUB1). Through its capacity to contribute to mitotic arrest, BUB1 functions as an integral component of the spindle assembly checkpoint (SAC), a surveillance mechanism that delays mitotic progression until all kinetochores are properly attached to microtubules, and aligned at the spindle equator in metaphase. Since its original discovery in budding yeast, a SAC function for BUB1 has been verified in all model organisms studied to date (reviewed in (Elowe 2011). Soon after its...
KeywordsSpindle Assembly Checkpoint Mitotic Progression Kinetochore Localization Transform Growth Factor Beta Receptor Chromosome Congression
- Baron AP, von Schubert C, Cubizolles F, Siemeister G, Hitchcock M, Mengel A, et al. Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Elife. 2016;5. doi:10.7554/eLife.12187.Google Scholar
- Lee S, Thebault P, Freschi L, Beaufils S, Blundell TL, Landry CR, et al. Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases. J Biol Chem. 2012;287:5988–6001. doi:10.1074/jbc.M111.307355.CrossRefPubMedGoogle Scholar
- Vanoosthuyse V, Valsdottir R, Javerzat JP, Hardwick KG. Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p. Mol Cell Biol. 2004;24:9786–801. doi:10.1128/MCB.24.22.9786-9801.2004.CrossRefPubMedPubMedCentralGoogle Scholar
- Wang Z, Katsaros D, Shen Y, Fu Y, Canuto EM, Benedetto C, et al. Biological and clinical significance of MAD2L1 and BUB1, genes frequently appearing in expression signatures for breast cancer prognosis. PLoS One. 2015;10:e0136246. doi:10.1371/journal.pone.0136246.CrossRefPubMedPubMedCentralGoogle Scholar