Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi


  • Milan Obradovic
  • Julijana Stanimirovic
  • Anastasija Panic
  • Bozidarka Zaric
  • Esma R. Isenovic
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101543-1


Historical Background

Danish scientist, Jeans C. Skou, was the first who suggested a link between transport of sodium (Na +) and potassium (K +) across the plasma membrane and adenosine-triphosphatase (ATPase) activity in 1950s. For the discovery of the Na +/K +-ATPase, Jeans C. Skou was awarded by the Nobel Prize in Chemistry in 1997. This discovery was important for understanding the reaction of excitable cells (nervous cells) to the stimuli and transmission of impulses. The Na +/K +-ATPase is a membrane protein and has a role in the active transport of Na + and K + ions across the plasma membrane. For this transport, Na +/K +-ATPase uses the energy derived from the process of hydrolysis of the terminal phosphate bond of ATP. During this process, the acyl phosphate forms as intermediate. The Na +/K +-ATPase helps maintaining resting potential and import of amino acids, glucose and other nutrients into cells and regulates cellular volume...


ATPase Activity Cardiac Glycoside ATPase Subunit Auxiliary Subunit Equal Molar Ratio 
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This work is supported by grants No.173033 (to E.R.I) from the Ministry of Science, Republic of Serbia.


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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Milan Obradovic
    • 1
  • Julijana Stanimirovic
    • 1
  • Anastasija Panic
    • 1
  • Bozidarka Zaric
    • 2
  • Esma R. Isenovic
    • 1
  1. 1.Vinca Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular GeneticsUniversity of BelgradeBelgradeSerbia
  2. 2.Institute of Chemistry, Technology and Metallurgy, Department of ChemistryUniversity of BelgradeBelgradeSerbia