Located on chromosome 4q31.1 in humans, the gene NR3C2 encodes the mineralocorticoid receptor (Fan et al. 1989; Morrison et al. 1990). It has 5201 bp, an exon count of 12, and is located on chromosome 8 in mice, 19 in rats, 1 in zebra fish, and 4 in chickens. Mineralocorticoids (MRs) belong to the nuclear receptor subfamily 3 and are distributed throughout the epithelia of the kidneys, sweat glands, and colon and the nonepithelial tissues of the heart and brain. The human MR was first cloned in 1987, consists of 984 amino acids, and is similar in structure to the glucocorticoid receptor, sharing 94% identity in the DNA-binding domain (Funder 1997).
It is unique among steroid receptors in that it plays signaling roles in both mineralocorticoids (e.g., aldosterone and deoxycorticosterone) and the glucocorticoids (cortisol in humans, corticosterone in rats). In particular, both...
KeywordsMineralocorticoid Receptor Nuclear Receptor Subfamily Sodium Potassium Pump Presynaptic Glutamate Release Steroid Hormone Receptor Complex
- Bruner KL, Derfoul A, Robertson NM, Guerriero G, Fernandes-Alnemri T, Alnemri ES, et al. The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. Recept Sig Transduct. 1996;7:85–98.Google Scholar
- Fan YS, Eddy RL, Byers MG, Haley LL, Henry WM, Shows TB. Assignment of human mineralocorticoid receptor (Mlr) to human chromosome-4q31.2. Cytogenet Cell Genet. 1989;51:996.Google Scholar
- Hudson WH, Youn C, Ortlund EA. Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. PLoS One. 2014;9. doi:ARTN e10700081371/journal.pone.0107000.Google Scholar
- Prager EM, Brielmaier J, Bergstrom HC, McGuire J, Johnson LR. Localization of mineralocorticoid receptors at mammalian synapses. PLoS One. 2010;5. doi:ARTN e14344171371/journal.pone.0014344.Google Scholar
- Russo MF, Loy SRA, Battle AR, Johnson LR. Membrane associated synaptic mineralocorticoid and glucocorticoid receptors are rapid regulators of dendritic spines. Front Cell Neurosci. 2016;10.Google Scholar