Glucocorticoid Receptor (GR)
The gene NR3C1 encoding the glucocorticoid receptor (GR) is located on chromosome 5q31.3 in humans, chromosome 18 in rats and mice, and chromosome 13 in chickens (Flaherty et al. 2012). It counts 2201 bp and contains 15 exons. The five prime untranslated region consists of exon 1 while the protein-encoding region involves exons 2–9. Homologs are conserved in chimpanzees, dogs, rats, zebra fish, and frogs. The structural organization of the GR arises from exons 2 to 9 and includes a DNA-binding domain and hinge region between the N and C termini. Exon 2 codes the N-terminal domain. Exons 3 and 4 encode the DNA-binding domain consisting of two zinc fingers. The GR consists of 777 amino acids and is expressed throughout the body. Subcellular locations include the cytoplasm, mitochondrion, cell nucleus, and plasma membrane. It is...
KeywordsChronic Obstructive Pulmonary Disease Glucocorticoid Receptor Fluticasone Propionate Mineralocorticoid Receptor Glucocorticoid Response Element
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