The first evidence of an active transport of serotonin (5-hydroxytryptamine, 5-HT) came from pioneer studies in the late 1950s showing an uptake of 5-HT into the blood platelets from rabbit or guinea pig. A few years later, a similar mechanism was observed in the rat brain (Schanberg 1963). The mechanism of this transport, involving the sodium and potassium ionic gradients, was rapidly elucidated, and the existence of a dedicated transporter protein postulated. In addition, the antidepressant imipramine was shown to bind to this putative transporter to reduce 5-HT uptake into the blood platelet, and, therefore, the serotonin transporter was named the “serotonin transporter-imipramine receptor.” Using the binding properties of imipramine to the serotonin transporter, Jane Talvenheimo and Gary Rudnick have purified the transporter...
KeywordsSerotonin Transporter polyA Signal Reuptake Activity Extracellular Vestibule Transcription Factor CTCF
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