Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

ATP-Binding Cassette Subfamily A Member 2

  • Soheila Rahgozar
  • Narges Aberuyi
  • Hadi Moafi
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101528-1

Synonyms

Historical Background

ATP-binding cassette (ABC) transporters are integral membrane proteins that cross the intracellular (organelles) and cytoplasmic membranes and are involved directly in the transport of substrates against a concentration gradient using ATP hydrolysis. The superfamily of human ABC transporters comprises 49 members and has a wide variety of functions. This family is divided into seven subfamilies from A to G, with the ABC “A” subfamily containing 13 members, such as ABCA1, ABCA2, and ABCA7, which transport sterols. The second member of the ABCA subfamily is named ABCA2. It is expressed at high levels in the white matter of the brain (Halene et al. 2016), as well as oligodendrocytes, schwann cells, excitatory and inhibitory neurons (Mack...

Keywords

Amyloid Precursor Protein Vestibular Schwannoma ABCA2 Gene ABCA2 Protein Amyloid Precursor Protein Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of BiologyUniversity of IsfahanIsfahanIran
  2. 2.University of IsfahanIsfahanIran
  3. 3.University of British ColumbiaVancouverCanada