Skip to main content
SpringerLink
Log in

5-Hydroxytryptamine Receptor 6

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 134 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Bruin MNWJ, McCreary AC, van Loevezijn A, de Vries TJ, Venhorst J, Drimmelen M, et al. A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats. Behav Brain Res. 2013;236:157–65. doi:10.1016/j.bbr.2012.08.048.

    Article  PubMed  Google Scholar 

  • Codony X, Vela JM, Ramírez MJ. 5-HT6 receptor and cognition. Curr Opin Pharmacol. 2011;11(1):94–100. doi:10.1016/j.coph.2011.01.004.

    Article  CAS  PubMed  Google Scholar 

  • Di Chiara G, Valentini V, Fenu S. Behavioral and neurochemical pharmacology of 5-ht6 receptors related to reward and reinforcement. In: Borsini F, editor. International review of neurobiology, Pharmacology of 5-HT6 receptors, part II, vol. 96; 2011. p. 111–39. doi:10.1016/B978-0-12-385902-0.00005-X.

    Google Scholar 

  • Heal DJ, Smith SL, Fisas A, Codony X, Buschmann H. Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. Pharmacol Ther. 2008;117(2):207–31. doi:10.1016/j.pharmthera.2007.08.006.

    Article  CAS  PubMed  Google Scholar 

  • Helboe L, Egebjerg J, De Jong IEM. Distribution of serotonin receptor 5-HT6 mRNA in rat neuronal subpopulations: a double in situ hybridization study. Neuroscience. 2015;310:442–54. doi:10.1016/j.neuroscience.2015.09.064.

    Article  CAS  PubMed  Google Scholar 

  • Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, et al. Differences in the central nervous system distribution and pharmacology of the mouse 5- hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharmacol. 2003;64(6):1295–308. doi:10.1124/mol.64.6.1295.

    Article  CAS  PubMed  Google Scholar 

  • Karila D, Freret T, Bouet V, Boulouard M, Dallemagne P, Rochais C. Therapeutic potential of 5-HT 6 receptor agonists. J Med Chem. 2015;58(20):7901–12. doi:10.1021/acs.jmedchem.5b00179.

    Article  CAS  PubMed  Google Scholar 

  • Knudsen GM, Hasselbalch SG. Imaging of the serotonin system: radiotracers and applications in memory disorders. In: Dierckx RAJO, Otte A, de Vries EFJ, van Waarde A, Luiten PGM, editors. PET and SPECT of neurobiological systems. Berlin/Heidelberg: Springer; 2014. p. 669–86. doi:10.1007/978-3-642-42014-6_23.

    Chapter  Google Scholar 

  • Marazziti D, Baroni S, Borsini F, Picchetti M, Vatteroni E, Falaschi V, et al. Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology. Curr Med Chem. 2013;20:371–7. doi:10.2174/0929867311320030008.

    CAS  PubMed  Google Scholar 

  • Messina D, Annesi G, Serra P, Nicoletti G, Pasqua A, Annesi F, et al. Association of the 5-HT6 receptor gene polymorphism C267T with Parkinson’s disease. Neurology. 2002;58(5):828–9. doi:10.1212/WNL.58.5.828.

    Article  CAS  PubMed  Google Scholar 

  • Monsma F, Shen Y, Ward RP, Hamblin MW, Sibley DR. Cloning and expression of a novel serotonin receptor with affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993;43(3):320–7.

    CAS  PubMed  Google Scholar 

  • Müller CP, Pum ME, Schumann G, Huston JP. The role of serotonin in drug addiction. In: Müller CP, Jacobs BL, editors. Handbook of behavioral neuroscience, vol. 21; 2010. p. 507–45. doi:10.1016/S1569-7339(10)70099-0.

    Google Scholar 

  • Pereira M, Martynhak BJ, Andreatini R, Svenningsson P. 5-HT6 receptor agonism facilitates emotional learning. Front Pharmacol. 2015;16(6):200. doi:10.3389/fphar.2015.00200.

    Google Scholar 

  • Roth BL, Craigo SC, Choudhary MS, Uluer A, Monsma Jr FJ, Shen Y, et al. Binding of typical and atypical antipsychotic agents to 5- hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994;268(3):1403–10.

    CAS  PubMed  Google Scholar 

  • Ruat M, Traiffort E, Arrang JM, Tardivel-Lacombe J, Diaz J, Leurs R, et al. A novel rat serotonin (5-HT6) receptor: molecular cloning localization and stimulation of cAMP. Biochem Biophys Res Commun. 1993;193(1):268–76. doi:10.1006/bbrc.1993.1619.

    Article  CAS  PubMed  Google Scholar 

  • Schechter LE, Lin Q, Smith DL, Zhang G, Shan Q, Platt B, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008;33(6):1323–5. doi:10.1038/sj.npp.1301503.

    Article  CAS  PubMed  Google Scholar 

  • Tsai SJ, Liu HC, Liu TY, Wang YC, Hong CJ. Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer’s disease. Neurosci Lett. 1999;276(2):138–9.

    Article  CAS  PubMed  Google Scholar 

  • Usworth C, Molinoff P. Characterization of a 5-hyroxytyptamine receptor in mouse neuroblastoma N18TG2 cells. J Pharmacol Exp Ther. 1994;269:245–55. doi:10.1016/j.ejphar.2011.03.020.

    Google Scholar 

  • Woods S, Clarke NN, Layfield R, Fone KC. 5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms. Br J Pharmacol. 2012;167(2):436–49. doi:10.1111/j.1476-5381.2012.02022.x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Woolley ML, Bentley JC, Sleight AJ, Marsden CA, Fone KC. A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology. 2001;41(2):210–9. doi:10.1016/S0028-3908(01)00056-9.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgment

Author financial support: CAPES (Coordination for the Improvement of Higher Education Personnel).

Author information

Authors and Affiliations

  1. Department of clinical neuroscience, Center of Molecular Medicine L801, Karolinska Institutet - Karolinska University Hospital, Solna, 171 76, Stockholm, Sweden

    Marcela Pereira

Authors
  1. Marcela Pereira
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marcela Pereira .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Pereira, M. (2016). 5-Hydroxytryptamine Receptor 6. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101490-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101490-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation