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Peptide Pheromones and Their Protein Receptors: Cellular Signaling in Gram-Positive Bacteria

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References

  • Agaisse H, Gominet M, Okstad OA, Kolsto AB, Lereclus D (1999) PlcR is a pleiotropic regulator of extracellular virulence factor gene expression in Bacillus thuringiensis. Mol Microbiol 32:1043–1053

    Article  CAS  PubMed  Google Scholar 

  • An FY, Sulavik MC, Clewell DB (1999) Identification and characterization of a determinant (eep) on the Enterococcus faecalis chromosome that is involved in production of the peptide sex pheromone cAD1. J Bacteriol 181:5915–5921

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ansaldi M, Marolt D, Stebe T, Mandic-Mulec I, Dubnau D (2002) Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants. Mol Microbiol 44:1561–1573

    Article  CAS  PubMed  Google Scholar 

  • Antiporta MH, Dunny GM (2002) ccfA, the genetic determinant for the cCF10 peptide pheromone in Enterococcus faecalis OG1RF. J Bacteriol 184:1155–1162

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bacon Schneider K, Palmer TM, Grossman AD (2002) Characterization of comQ and comX, two genes required for production of ComX pheromone in Bacillus subtilis. J Bacteriol 184:410–419

    Article  PubMed  Google Scholar 

  • Bae T, Kozlowicz B, Dunny GM (2002) Two targets in pCF10 DNA for PrgX binding: their role in production of Qa and prgX mRNA and in regulation of pheromone-inducible conjugation. J Mol Biol 315:995–1007

    Article  CAS  PubMed  Google Scholar 

  • Blatch GL, Lassle M (1999) The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays 21:932–939

    Article  CAS  PubMed  Google Scholar 

  • Bouillaut L, Perchat S, Arold S, Zorrilla S, Slamti L, Henry C, Gohar M, Declerck N, Lereclus D (2008) Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptides. Nucleic Acids Res 36:3791–3801

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Chang JC, Lasarre B, Jimenez JC, Aggarwal C, Federle MJ (2011) Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development. PLoS Pathog 7:e1002190

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Claverys JP, Havarstein LS (2002) Extracellular-peptide control of competence for genetic transformation in Streptococcus pneumoniae. Front Biosci 7:d1798–d1814

    Article  CAS  PubMed  Google Scholar 

  • Claverys JP, Havarstein LS (2007) Cannibalism and fratricide: mechanisms and raisons d’etre. Nat Rev Microbiol 5:219–229

    Article  CAS  PubMed  Google Scholar 

  • Clewell DB (1990) Movable genetic elements and antibiotic resistance in enterococci. Eur J Clin Microbiol Infect Dis 9:90–102

    Article  CAS  PubMed  Google Scholar 

  • Core L, Perego M (2003) TPR-mediated interaction of RapC with ComA inhibits response regulator-DNA binding for competence development in Bacillus subtilis. Mol Microbiol 49:1509–1522

    Article  CAS  PubMed  Google Scholar 

  • D’Andrea LD, Regan L (2003) TPR proteins: the versatile helix. Trends Biochem Sci 28:655–662

    Article  PubMed  Google Scholar 

  • Declerck N, Bouillaut L, Chaix D, Rugani N, Slamti L, Hoh F, Lereclus D, Arold ST (2007) Structure of PlcR: insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria. Proc Natl Acad Sci U S A 104:18490–18495

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dubois T, Faegri K, Perchat S, Lemy C, Buisson C, Nielsen-LeRoux C, Gohar M, Jacques P, Ramarao N, Kolsto AB, Lereclus D (2012) Necrotrophism is a quorum-sensing-regulated lifestyle in Bacillus thuringiensis. PLoS Pathog 8:e1002629

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dunny GM (2007) The peptide pheromone-inducible conjugation system of Enterococcus faecalis plasmid pCF10: cell-cell signalling, gene transfer, complexity and evolution. Philos Trans R Soc Lond B Biol Sci 362:1185–1193

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dunny GM, Johnson CM (2011) Regulatory circuits controlling enterococcal conjugation: lessons for functional genomics. Curr Opin Microbiol 14:174–180

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dunny GM, Leonard BA (1997) Cell-cell communication in gram-positive bacteria. Annu Rev Microbiol 51:527–564

    Article  CAS  PubMed  Google Scholar 

  • Dunny G, Funk C, Adsit J (1981) Direct stimulation of the transfer of antibiotic resistance by sex pheromones in Streptococcus faecalis. Plasmid 6:270–278

    Article  CAS  PubMed  Google Scholar 

  • Federle M (2012) Pathogenic streptococci speak, but what are they saying? Virulence 3:92–94

    Article  PubMed Central  PubMed  Google Scholar 

  • Federle MJ, Bassler BL (2003) Interspecies communication in bacteria. J Clin Invest 112:1291–1299

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Federle MJ, Morrison DA (2012) One if by land, two if by sea: signalling to the ranks with CSP and XIP. Mol Microbiol 86:241–245

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Fleuchot B, Gitton C, Guillot A, Vidic J, Nicolas P, Besset C, Fontaine L, Hols P, Leblond-Bourget N, Monnet V, Gardan R (2011) Rgg proteins associated with internalized small hydrophobic peptides: a new quorum-sensing mechanism in streptococci. Mol Microbiol 80:1102–1119

    Article  CAS  PubMed  Google Scholar 

  • Fontaine L, Boutry C, de Frahan MH, Delplace B, Fremaux C, Horvath P, Boyaval P, Hols P (2010) A novel pheromone quorum-sensing system controls the development of natural competence in Streptococcus thermophilus and Streptococcus salivarius. J Bacteriol 192:1444–1454

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gohar M, Faegri K, Perchat S, Ravnum S, Okstad OA, Gominet M, Kolsto AB, Lereclus D (2008) The PlcR virulence regulon of Bacillus cereus. PLoS One 3:e2793

    Article  PubMed Central  PubMed  Google Scholar 

  • Gominet M, Slamti L, Gilois N, Rose M, Lereclus D (2001) Oligopeptide permease is required for expression of the Bacillus thuringiensis plcR regulon and for virulence. Mol Microbiol 40:963–975

    Article  CAS  PubMed  Google Scholar 

  • Grenha R, Slamti L, Nicaise M, Refes Y, Lereclus D, Nessler S (2012) Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR. Proc Natl Acad Sci U S A 110:1047–1052

    Article  PubMed Central  PubMed  Google Scholar 

  • Havarstein LS, Coomaraswamy G, Morrison DA (1995) An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae. Proc Natl Acad Sci U S A 92:11140–11144

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hui FM, Morrison DA (1991) Genetic transformation in Streptococcus pneumoniae: nucleotide sequence analysis shows comA, a gene required for competence induction, to be a member of the bacterial ATP-dependent transport protein family. J Bacteriol 173:372–381

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ibrahim M, Guillot A, Wessner F, Algaron F, Besset C, Courtin P, Gardan R, Monnet V (2007a) Control of the transcription of a short gene encoding a cyclic peptide in Streptococcus thermophilus: a new quorum-sensing system? J Bacteriol 189:8844–8854

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ibrahim M, Nicolas P, Bessieres P, Bolotin A, Monnet V, Gardan R (2007b) A genome-wide survey of short coding sequences in streptococci. Microbiology 153:3631–3644

    Article  CAS  PubMed  Google Scholar 

  • Irie Y, Parsek MR (2008) Quorum sensing and microbial biofilms. Curr Top Microbiol Immunol 322:67–84

    CAS  PubMed  Google Scholar 

  • Karpenahalli MR, Lupas AN, Soding J (2007) TPRpred: a tool for prediction of TPR-, PPR- and SEL1-like repeats from protein sequences. BMC Bioinformatics 8:2

    Article  PubMed Central  PubMed  Google Scholar 

  • Kavanaugh JS, Thoendel M, Horswill AR (2007) A role for type I signal peptidase in Staphylococcus aureus quorum sensing. Mol Microbiol 65:780–798

    Article  CAS  PubMed  Google Scholar 

  • LaSarre B, Aggarwal C, Federle MJ (2013) Antagonistic Rgg regulators mediate quorum sensing via competitive DNA binding in Streptococcus pyogenes. MBio 3:e00333. doi:10.1128/mBio.00333-12

    Article  PubMed  Google Scholar 

  • Lereclus D, Agaisse H, Gominet M, Salamitou S, Sanchis V (1996) Identification of a Bacillus thuringiensis gene that positively regulates transcription of the phosphatidylinositol-specific phospholipase C gene at the onset of the stationary phase. J Bacteriol 178:2749–2756

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lereclus D, Agaisse H, Grandvalet C, Salamitou S, Gominet M (2000) Regulation of toxin and virulence gene transcription in Bacillus thuringiensis. Int J Med Microbiol 290:295–299

    Article  CAS  PubMed  Google Scholar 

  • Magnuson R, Solomon J, Grossman AD (1994) Biochemical and genetic characterization of a competence pheromone from B. subtilis. Cell 77:207–216

    Article  CAS  PubMed  Google Scholar 

  • Mashburn-Warren L, Morrison DA, Federle MJ (2010) A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator. Mol Microbiol 78:589–606

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Mashburn-Warren L, Morrison DA, Federle MJ (2012) The cryptic competence pathway in Streptococcus pyogenes is controlled by a peptide pheromone. J Bacteriol 194:4589–4600

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Miller MB, Bassler BL (2001) Quorum sensing in bacteria. Annu Rev Microbiol 55:165–199

    Article  CAS  PubMed  Google Scholar 

  • Mori M, Sakagami Y, Ishii Y, Isogai A, Kitada C, Fujino M, Adsit JC, Dunny GM, Suzuki A (1988) Structure of cCF10, a peptide sex pheromone which induces conjugative transfer of the Streptococcus faecalis tetracycline resistance plasmid, pCF10. J Biol Chem 263:14574–14578

    CAS  PubMed  Google Scholar 

  • Ng WL, Bassler BL (2009) Bacterial quorum-sensing network architectures. Annu Rev Genet 43:197–222

    Article  CAS  PubMed  Google Scholar 

  • Novick RP (2003) Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 48:1429–1449

    Article  CAS  PubMed  Google Scholar 

  • Novick RP, Geisinger E (2008) Quorum sensing in staphylococci. Annu Rev Genet 42:541–564

    Article  CAS  PubMed  Google Scholar 

  • Okada M (2011) Post-translational isoprenylation of tryptophan. Biosci Biotechnol Biochem 75:1413–1417

    Article  CAS  PubMed  Google Scholar 

  • Okada M, Sato I, Cho SJ, Iwata H, Nishio T, Dubnau D, Sakagami Y (2005) Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX. Nat Chem Biol 1:23–24

    Article  CAS  PubMed  Google Scholar 

  • Okada M, Yamaguchi H, Sato I, Tsuji F, Dubnau D, Sakagami Y (2008) Chemical structure of posttranslational modification with a farnesyl group on tryptophan. Biosci Biotechnol Biochem 72:914–918

    Article  CAS  PubMed  Google Scholar 

  • Perchat S, Dubois T, Zouhir S, Gominet M, Poncet S, Lemy C, Aumont-Nicaise M, Deutscher J, Gohar M, Nessler S, Lereclus D (2011) A cell-cell communication system regulates protease production during sporulation in bacteria of the Bacillus cereus group. Mol Microbiol 83:619–633

    Article  Google Scholar 

  • Perego M, Hoch JA (1996) Protein aspartate phosphatases control the output of two-component signal transduction systems. Trends Genet 12:97–101

    Article  CAS  PubMed  Google Scholar 

  • Perego M, Hanstein C, Welsh KM, Djavakhishvili T, Glaser P, Hoch JA (1994) Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilis. Cell 79:1047–1055

    Article  CAS  PubMed  Google Scholar 

  • Pomerantsev AP, Pomerantseva OM, Camp AS, Mukkamala R, Goldman S, Leppla SH (2009) PapR peptide maturation: role of the NprB protease in Bacillus cereus 569 PlcR/PapR global gene regulation. FEMS Immunol Med Microbiol 55:361–377

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Pottathil M, Lazazzera BA (2003) The extracellular Phr peptide-Rap phosphatase signaling circuit of Bacillus subtilis. Front Biosci 8:d32–d45

    Article  PubMed  Google Scholar 

  • Qiu R, Pei W, Zhang L, Lin J, Ji G (2005) Identification of the putative staphylococcal AgrB catalytic residues involving the proteolytic cleavage of AgrD to generate autoinducing peptide. J Biol Chem 280:16695–16704

    Article  CAS  PubMed  Google Scholar 

  • Rocha-Estrada J, Aceves-Diez AE, Guarneros G, de la Torre M (2010) The RNPP family of quorum-sensing proteins in Gram-positive bacteria. Appl Microbiol Biotechnol 87:913–923

    Article  CAS  PubMed  Google Scholar 

  • Shi K, Brown CK, Gu ZY, Kozlowicz BK, Dunny GM, Ohlendorf DH, Earhart CA (2005) Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis. Proc Natl Acad Sci U S A 102:18596–18601

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Slamti L, Lereclus D (2002) A cell-cell signaling peptide activates the PlcR virulence regulon in bacteria of the Bacillus cereus group. EMBO J 21:4550–4559

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Straight PD, Kolter R (2009) Interspecies chemical communication in bacterial development. Annu Rev Microbiol 63:99–118

    Article  CAS  PubMed  Google Scholar 

  • Sulavik MC, Tardif G, Clewell DB (1992) Identification of a gene, rgg, which regulates expression of glucosyltransferase and influences the Spp phenotype of Streptococcus gordonii Challis. J Bacteriol 174:3577–3586

    CAS  PubMed Central  PubMed  Google Scholar 

  • Thoendel M, Kavanaugh JS, Flack CE, Horswill AR (2011) Peptide signaling in the staphylococci. Chem Rev 111:117–151

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Tzeng YL, Feher VA, Cavanagh J, Perego M, Hoch JA (1998) Characterization of interactions between a two-component response regulator, Spo0F, and its phosphatase, RapB. Biochemistry 37:16538–16545

    Article  CAS  PubMed  Google Scholar 

  • Waters CM, Bassler BL (2005) Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol 21:319–346

    Article  CAS  PubMed  Google Scholar 

  • Yim G, Wang HH, Davies J (2007) Antibiotics as signalling molecules. Philos Trans R Soc Lond B Biol Sci 362:1195–1200

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Zhang L, Gray L, Novick RP, Ji G (2002) Transmembrane topology of AgrB, the protein involved in the post-translational modification of AgrD in Staphylococcus aureus. J Biol Chem 277:34736–34742

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported in part by a grant from the NIH NIAID, R01-AI091779. This work was partially funded by the Chicago Biomedical Consortium with support from the Searle Funds at The Chicago Community Trust.

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Authors and Affiliations

  1. Center for Pharmaceutical Biotechnology, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 3152 MBRB (M/C 870), 900 S. Ashland Ave, Chicago, IL, 60607, USA

    Chaitanya Aggarwal & Michael J. Federle

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  1. Chaitanya Aggarwal
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  2. Michael J. Federle
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Correspondence to Michael J. Federle .

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  1. Dept of Chemistry, University of Richmond, Richmond, Virginia, USA

    Ellis Bell

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Aggarwal, C., Federle, M.J. (2014). Peptide Pheromones and Their Protein Receptors: Cellular Signaling in Gram-Positive Bacteria. In: Bell, E. (eds) Molecular Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6436-5_740-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6436-5_740-1

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