Fig. 12

Structures of site-specific recombinases bound to DNA. (a) Synaptic complex of four Cre monomers bound to loxP sites in two dsDNA molecules (black lines) (From PDB ID 2HOI (Ghosh et al. 2007)). (b) One Cre monomer from the structure in (a) is shown, rotated by about 90 Ε relative to the image in (a). The active site tyrosine (Tyr-324) is shown in spacefill. (c) Lambda integrase (Int) tetramer bound to a Holliday junction intermediate (From PDB ID 1Z1G (Biswas et al. 2005))