Fig. 10

Branch migration promoted by RuvAB. A RuvA tetramer (green square) binds to the center of a Holliday junction. Two RuvB hexamers (blue rings) encircle the DNA duplexes on opposite sides of RuvA. ATP hydrolysis catalyzed by RuvB enables the protein to pull the DNA through the center of the ring. The DNA base pairs are disrupted as they are pulled past peptide protrusions (gray triangles) in RuvA, and the base pairs reform as they head toward the RuvB rings (After Parsons et al. 1995)