Innate B Cells
B cells have long been appreciated to play a central role in adaptive immunity through their production of antigen-specific antibodies in response to activated T cells. It is now known that innate B cell populations exist that provide rapid protection against pathogens by secreting antibodies without T cell help. Recently, a B cell population has been discovered that regulates immune responses through cytokine secretion. This minireview will cover our current understanding of these B cell subsets in rodents as well as B cell populations in humans which may serve similar functions.
Experiments with germ-free mice have demonstrated that antibodies are generated in the absence of microbial exposure. Such antibodies are referred to as natural antibodies. They target microbial antigens such as bacterial cell wall polysaccharides and viral glycoproteins, but can also react to self-antigens including DNA, membrane proteins, and immunoglobulins. The antigens recognized by...
KeywordsExperimental Autoimmune Encephalomyelitis Dextran Sulfate Sodium Natural Antibody Common Variable Immunodeficiency CVID Patient
- Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ (2009) Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest 119(5):1335–1349PubMedCentralPubMedCrossRefGoogle Scholar
- Rakhmanov M, Keller B, Gutenberger S, Foerster C, Hoenig M, Driessen G, van der Burg M, van Dongen JJ, Wiech E, Visentini M, Quinti I, Prasse A, Voelxen N, Salzer U, Goldacker S, Fisch P, Eibel H, Schwarz K, Peter HH, Warnatz K (2009) Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells. Proc Natl Acad Sci U S A 106(32):13451–13456PubMedCentralPubMedCrossRefGoogle Scholar