Molecular Life Sciences

Living Edition
| Editors: Robert D. Wells, Judith S. Bond, Judith Klinman, Bettie Sue Siler Masters, Ellis Bell

Innate B Cells

Living reference work entry


B cells have long been appreciated to play a central role in adaptive immunity through their production of antigen-specific antibodies in response to activated T cells. It is now known that innate B cell populations exist that provide rapid protection against pathogens by secreting antibodies without T cell help. Recently, a B cell population has been discovered that regulates immune responses through cytokine secretion. This minireview will cover our current understanding of these B cell subsets in rodents as well as B cell populations in humans which may serve similar functions.


Experiments with germ-free mice have demonstrated that antibodies are generated in the absence of microbial exposure. Such antibodies are referred to as natural antibodies. They target microbial antigens such as bacterial cell wall polysaccharides and viral glycoproteins, but can also react to self-antigens including DNA, membrane proteins, and immunoglobulins. The antigens recognized by...


Experimental Autoimmune Encephalomyelitis Dextran Sulfate Sodium Natural Antibody Common Variable Immunodeficiency CVID Patient 
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  1. Alugupalli KR, Leong JM, Woodland RT, Muramatsu M, Honjo T, Gerstein RM (2004) B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379–390PubMedCrossRefGoogle Scholar
  2. Ansel KM, Harris RB, Cyster JG (2002) CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity 16(1):67–76PubMedCrossRefGoogle Scholar
  3. Baumgarth N (2011) The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol 11(1):34–46PubMedCrossRefGoogle Scholar
  4. Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ (2009) Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest 119(5):1335–1349PubMedCentralPubMedCrossRefGoogle Scholar
  5. DiLillo DJ, Matsushita T, Tedder TF (2010) B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Ann N Y Acad Sci 1183:38–57PubMedCrossRefGoogle Scholar
  6. Haas KM, Poe JC, Steeber DA, Tedder TF (2005) B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity 23(1):7–18PubMedCrossRefGoogle Scholar
  7. Ochsenbein AF, Fehr T, Lutz C, Suter M, Brombacher F, Hengartner H, Zinkernagel RM (1999) Control of early viral and bacterial distribution and disease by natural antibodies. Science 286(5447):2156–2159PubMedCrossRefGoogle Scholar
  8. Pillai S, Cariappa A, Moran ST (2005) Marginal zone B cells. Annu Rev Immunol 23:161–196PubMedCrossRefGoogle Scholar
  9. Rakhmanov M, Keller B, Gutenberger S, Foerster C, Hoenig M, Driessen G, van der Burg M, van Dongen JJ, Wiech E, Visentini M, Quinti I, Prasse A, Voelxen N, Salzer U, Goldacker S, Fisch P, Eibel H, Schwarz K, Peter HH, Warnatz K (2009) Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells. Proc Natl Acad Sci U S A 106(32):13451–13456PubMedCentralPubMedCrossRefGoogle Scholar
  10. Weill JC, Weller S, Reynaud CA (2009) Human marginal zone B cells. Annu Rev Immunol 27:267–285PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Digestive Diseases, Department of MedicineUniversity of California, Los AngelesLos AngelesUSA