Periventricular leukomalacia (PVL) is the most common ischemic brain injury in premature infants and occurs in the white matter adjacent to the lateral ventricles, just distal to the regions supplied by the deep branches of the middle cerebral arteries. PVL is diagnosed by the typical findings of echodensities on cerebral ultrasound or signal abnormalities of MRI. PVL is an important finding because of the high association with later development of nonprogressive developmental impairments such as cerebral palsy.
References and Reading
- Volpe, J. J. (2008). Neurology of the newborn (5th ed.). Philadelphia: Saunders Elsevier. Chapter 8.Google Scholar