Sleep Regulation and Insomnia

  • Eus van Someren
  • Raymond Cluydts
Living reference work entry


For years, the subject of sleep failed to generate much interest from either the field of medicine or that of psychology – a curious fact, as a 60-year-old has spent some 20 years out of those 60 sleeping. In fact, up until the age of approximately 3 years, a child spends more time asleep than awake. It would be an extraordinary evolutionary oversight if this phenomenon of sleep, which is seen in virtually all organisms, did not have an important and vital function (McNamara, Evolution of sleep phylogenetic and functional perspectives. Cambridge University Press, Cambridge, 2009). The consequences of sleep deprivation make themselves known by interfering with our emotional and cognitive functioning on the following day, when one may also experience the imperative nature of sleep, sometimes at very inconvenient moments (Cluydts, Sleep Med Rev 7(4):293–295, 2003).


Acetylcholine Ascending reticular activating system (ARAS) Association of Sleep Disorders Centers Benzodiazepines Cognitive-behavioral therapy (CBT) Histamine Hypocretin-producing neurons Idiopathic insomnia Insomnia Inadequate sleep hygiene Paradoxal insomnia Psychophysiological insomnia Neuronal control Non-REM sleep REM sleep Wakefulness Psychophysiological insomnia Sleep Consequences of Deep sleep EEG traces Flip-flop system Sleep disorders Sleeping and waking Neurobiology Affective disorders Behavioral interventions Cognitive restructuring ICSD-2 classification Insomnia Pharmacology Psychoeducation Relaxation Sleep restriction Stimulus control Suprachiasmatic nucleus (SCN) Ventrolateral preoptic nucleus (VLPO) 


  1. Altena E, Van Der Werf YD, Sanz-Arigita EJ, Voorn T, Rombouts SARB, Kuijer JPA, Van Someren EJW (2008a) Prefrontal hypoactivation and recovery in insomnia. Sleep 31:1271–1276PubMedPubMedCentralGoogle Scholar
  2. Altena E, Van Der Werf YD, Strijers RLM, Van Someren EJW (2008b) Sleep loss affects vigilance. Effects of chronic insomnia and sleep therapy. J Sleep Res 17:335–343PubMedCrossRefGoogle Scholar
  3. Altena E, Vrenken H, Van Der Werf YD, Van Den Heuvel OAV, Van Someren EJW (2010) Reduced orbitofrontal and parietal grey matter in chronic insomnia: a voxel-based morphometric study. Biol Psychiatry 67:182–185PubMedCrossRefGoogle Scholar
  4. American Academy of Sleep Medicine (2005) International classification of sleep disorders, 2nd edn, Diagnostic and coding manual. American Academy of Sleep Medicine, WestchesterGoogle Scholar
  5. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, DC, revisedGoogle Scholar
  6. Ancoli-Israel S (2005) Long-term use of sedative hypnotics in older patients with insomnia. Sleep Med 6:107–113PubMedCrossRefGoogle Scholar
  7. Arendt J, Skene DJ (2005) Melatonin as a chronobiotic. Sleep Med Rev 9:25–39PubMedCrossRefGoogle Scholar
  8. Aserinsky E, Kleitman N (1953) Regularly occurring periods of eye motility, and concomitant phenomena, curing sleep. Science 118:273–274PubMedCrossRefGoogle Scholar
  9. Aston-Jones G, Meijas-Aponte CA, Waterhouse B (2009) Norepinephrine: CNS pathways and neurophysiology. In: Squire LR (ed) Encyclopedia of neuroscience. Academic, Oxford, pp 1237–1248CrossRefGoogle Scholar
  10. Banks S, Dinges DF (2007) Behavioral and physiological consequences of sleep restriction. J Clin Sleep Med 3:519–528PubMedPubMedCentralGoogle Scholar
  11. Barkoukis TJ, Avidan AY (2007) Review of sleep medicine. Elsevier Health Sciences, PhiladelphiaGoogle Scholar
  12. Basheer R, McKenna JT, McCarley RW (2009) Pharmacology of sleep: adenosine. In: Squire LR (ed) Encyclopedia of neuroscience. Academic, Oxford, pp 601–610CrossRefGoogle Scholar
  13. Benca R (2004) Special considerations in insomnia diagnosis and management: depressed, elderly, and chronic pain populations. J Clin Psychiatry 65:S26–S35Google Scholar
  14. Bonnet MH, Arand DL (1997) Hyperarousal and insomnia. Sleep Med Rev 1(2):97–108PubMedCrossRefGoogle Scholar
  15. Bonnet MH, Arand DL (2003) Situational insomnia: consistency, predictors, and outcomes. Sleep 26(8):1029–1036PubMedGoogle Scholar
  16. Borbely A, Achermann P (2005) Sleep homeostasis and models of sleep regulation. In: Kryger MH, Roth T, Dement WC (eds) Principles and practice of sleep medicine, 4th edn. W.B Saunders, Philadelphia, pp 405–417CrossRefGoogle Scholar
  17. Brzezinski A, Vangel MG, Wurtman RJ, Norrie G, Zhdanova I, Ben-Shushan A, Ford I (2005) Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev 9(1):41–50PubMedCrossRefGoogle Scholar
  18. Campbell SS, Dawson D, Anderson MW (1993) Alleviation of sleep maintenance insomnia with timed exposure to bright light. J Am Geriatr Soc 41:829–836PubMedCrossRefGoogle Scholar
  19. Carlson NR (2000) Physiology of behavior. Allyn and Bacon, BostonGoogle Scholar
  20. Carskadon MA, Rechtschaffen A (2005) Monitoring and staging human sleep. In: Kryger MK, Roth T, Dement WC (eds) Principles and practice of sleep medicine, 4th edn. Elsevier, Philadelphia, pp 1359–1377CrossRefGoogle Scholar
  21. Cirelli C, Tononi G (2008) Is sleep essential? PLoS Biol 6(8):1605–1611CrossRefGoogle Scholar
  22. Cluydts R (2003) Comparing the effects of sleep loss after experimental sleep deprivation and in clinical patients. Sleep Med Rev 7(4):293–295PubMedCrossRefGoogle Scholar
  23. Curry DT, Eisenstein RD, Walsh JK (2006) Pharmacologic management of insomnia: past, present, and future. Psychiatr Clin North Am 29(4):871–893PubMedCrossRefGoogle Scholar
  24. Czeisler C, Buxton OM, Khalsa SBS (2005) The human circadian timing system and sleep-wake regulation. In: Kryger MH, Roth T, Dement WC (eds) Principles and practice of sleep medicine, 4th edn. W.B Saunders, Philadelphia, pp 375–394CrossRefGoogle Scholar
  25. Dijk DJ, Archer SN (2009) PERIOD3, circadian phenotypes, and sleep homeostasis. Sleep Med Rev 14(3):151–160PubMedCrossRefGoogle Scholar
  26. Dowling GA, Burr RL, Van Someren EJW, Hubbard EM, Luxenberg JS, Mastick J, Cooper BA (2008) Melatonin and bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. J Am Geriatr Soc 56:239–246PubMedPubMedCentralCrossRefGoogle Scholar
  27. Edinger JD, Fins AI (1995) The distribution and clinical significance of sleep time misperceptions among insomniacs. Sleep 18(4):232–239PubMedGoogle Scholar
  28. Edinger JD, Krystal AD (2003) Subtyping primary insomnia: is sleep state misperception a distinct clinical entity? Sleep Med Rev 7(3):203–214PubMedCrossRefGoogle Scholar
  29. Edinger JD, Bonnet MH, Bootzin RR, Doghramji K, Dorsey CM, Espie CA, Jamieson AO, McCall VW, Morin CM, Stepanski EJ (2004) Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep 27:1567–1596PubMedGoogle Scholar
  30. Espie CA, Broomfield NM, MacMahon KMA, Macphee LM, Taylor LM (2006) The attention-intention-effort pathway in the development of psychophysiologic insomnia: a theoretical review. Sleep Med Rev 10(4):215–245PubMedCrossRefGoogle Scholar
  31. Fort P, Bassetti CL, Luppi PH (2009) Alternating vigilance states: new insights regarding neuronal networks and mechanisms. Eur J Neurosci 29(9):1741–1753PubMedCrossRefGoogle Scholar
  32. Franken P, Dijk DJ (2009) Circadian clock genes and sleep homeostasis. Eur J Neurosci 29(9):1820–1829PubMedCrossRefGoogle Scholar
  33. Franzen PL, Buysse DJ (2008) Sleep disturbances and depression: risk relationships for subsequent depression and therapeutic implications. Dialogues Clin Neurosci 10(4):473–481PubMedPubMedCentralGoogle Scholar
  34. Fuller PM, Saper CB, Lu J (2007) The pontine REM switch: past and present. J Physiol 584(3):735–741PubMedPubMedCentralCrossRefGoogle Scholar
  35. Gasio PF, Kräuchi K, Cajochen C, Van Someren EJW, Amrhein I, Pache M, Savaskan E, Wirz-Justice A (2003) Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly. Exp Gerontol 38:207–216CrossRefGoogle Scholar
  36. Glass J, Lanctôt KL, Herrmann N, Sproule BA, Busto UE (2005) Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. Br Med J 331:1169CrossRefGoogle Scholar
  37. Haas HL, Selbach O, Sergeeva OA (2009) Sleep and sleep states: histamine role. In: Squire LR (ed) Encyclopedia of neuroscience. Academic, Oxford, pp 919–928CrossRefGoogle Scholar
  38. Hajak G (2002) “As needed” pharmacotherapy combined with stimulus control treatment in chronic insomnia-assessment of a novel intervention strategy in a primary care setting. Ann Clin Psychiatry 14:1–7PubMedCrossRefGoogle Scholar
  39. Harvey A (2002) A cognitive model of insomnia. Behav Res Ther 40:869–893PubMedCrossRefGoogle Scholar
  40. Iber C, Ancoli-Israel S, Chesson A, Quan SF (2007) The AASM manual for the scoring of sleep and associated events: rules, terminology, and technical specification. American Academy of Sleep Medicine, WestchesterGoogle Scholar
  41. Irwin M, Clark C, Kennedy B, Gillin JC, Ziegler M (2003) Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects. Brain Behav Immun 17(5):365–372PubMedCrossRefGoogle Scholar
  42. Jacobs GD, Pace-Schott EF, Stickgold R, Otto MW (2004) Cognitive behavior therapy and pharmacotherapy for insomnia: a randomized controlled trial and direct comparison. Arch Intern Med 164:1888–1896PubMedCrossRefGoogle Scholar
  43. Jenni OG, LeBourgeois MK (2006) Understanding sleep-wake behavior and sleep disorders in children: the value of a model. Curr Opin Psychiatry 19(3):282–287PubMedPubMedCentralCrossRefGoogle Scholar
  44. Jones BE (2009) Sleep-wake state regulation by acetylcholine. In: Squire LR (ed) Encyclopedia of neuroscience. Academic, Oxford, pp 1075–1078CrossRefGoogle Scholar
  45. Kerkhofs M, Lavie P (2000) Historical note: Frederic Bremer 1892–1982: a pioneer in sleep research. Sleep Med Rev 4(5):505–514PubMedCrossRefGoogle Scholar
  46. Krueger JM, Rector DM, Churchill L (2007) Sleep and cytokines. Sleep Med Clin 2(2):161–169PubMedPubMedCentralCrossRefGoogle Scholar
  47. Kryger MH, Roth T, Dement WC (2005) Principles and practice of sleep medicine. Elsevier/WB Saunders, PhiladelphiaGoogle Scholar
  48. Krystal AD, Walsh JW (2003) Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia. Sleep 26:793–799PubMedGoogle Scholar
  49. Kushida CA (2008) Handbook of sleep disorders, 2nd edn. Informa Health Care, New YorkGoogle Scholar
  50. Lack LC, Gradisar M, Van Someren EJW, Wright HR, Lushington K (2008) The relationship between insomnia and body temperatures. Sleep Med Rev 12:307–317PubMedCrossRefGoogle Scholar
  51. Lichstein KL, Durrence HH, Taylor DJ, Bush AJ, Riedel BW (2002) Quantitative criteria for insomnia. Behav Res Ther 41:427–445CrossRefGoogle Scholar
  52. Lichstein KL, Stone KC, Nau SD, McCrae CS, Payne KL (2006) Insomnia in the elderly. Sleep Med Clin 1(2):221–229CrossRefGoogle Scholar
  53. Lieverse R, Van Someren EJW, Nielen MM, Uitdehaag B, Smit JH, Hoogendijk WJ (2011) Bright light treatment improves mood, sleep and circadian rhythms in elderly patients with major depressive disorder. A randomized controlled trial. Arch Gen Psychiatry 68:61–70PubMedCrossRefGoogle Scholar
  54. Lu J, Sherman D, Devor M, Saper CB (2006) A putative flip-flop switch for control of REM sleep. Nature 441(7093):589–594PubMedCrossRefGoogle Scholar
  55. Manber R, Edinger JD, Gress JL, San Pedro-Salcedo MG, Kuo TF, Kalista T (2008) Cognitive behavioral therapy for insomnia enhances depression outcome in patients with comorbid major depressive disorder and insomnia. Sleep 31(4):447–448Google Scholar
  56. McCarley RW (2007) Neurobiology of REM and NREM sleep. Sleep Med 8(4):302–330PubMedCrossRefGoogle Scholar
  57. McNamara P (2009) Evolution of sleep phylogenetic and functional perspectives. Cambridge University Press, CambridgeCrossRefGoogle Scholar
  58. Meerlo P, Sgoifo A, De Boer SF, Koolhaas JM (1999) Long-lasting consequences of a social conflict in rats: behavior during the interaction predicts subsequent changes in daily rhythms of heart rate, temperature, and activity. Behav Neurosci 113(6):1283–1290PubMedCrossRefGoogle Scholar
  59. Mignot E (2008) Why we sleep: the temporal organization of recovery. PLoS Biol 6(4):661–669CrossRefGoogle Scholar
  60. Monti JM, Jantos H (2008) The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. In: Di Giovanni G, Di Matteo V, Esposito E (eds) Progress in brain research. Elsevier, New York, pp 625–646Google Scholar
  61. Morin CM (2006) Psychological and behavioral treatment of insomnia: update of the recent evidence (1998–2004). Sleep 29:1398–1414PubMedGoogle Scholar
  62. Morin CM, Espie CA (2003) Insomnia. A clinician’s guide to assessment and treatment. Springer, New YorkGoogle Scholar
  63. Morin CM, Rodrigue S, Ivers H (2003) Role of stress, arousal, and coping skills in primary insomnia. Psychosom Med 65(2):259–267PubMedCrossRefGoogle Scholar
  64. Moruzzi G, Magoun HW (1949) Brain stem reticular formation and activation of the EEG. Electroencephalogr Clin Neurophysiol 1:455–473PubMedCrossRefGoogle Scholar
  65. Moser D, Anderer P, Gruber G, Parapatics S, Loretz E, Boeck M, Kloesch G, Heller E, Schmidt A, Danker-Hopfe H, Saletu B, Zeitlhofer J, Dorffner G (2009) Sleep classification according to AASM and Rechtschaffen & Kales: effects on sleep scoring parameters. Sleep 32(2):139–149PubMedPubMedCentralGoogle Scholar
  66. Murillo-Rodríguez E, Arias-Carrión O, Sanguino-Rodríguez K, González-Arias M, Haro R (2009) Mechanisms of sleep-wake cycle modulation. CNS Neurol Disord Drug Targets 8(4):245–253PubMedCrossRefGoogle Scholar
  67. National Institutes of Health (2005) National institutes of health state of the science conference statement on manifestations and management of chronic insomnia in adults. Sleep 28:1049–1057Google Scholar
  68. Nierenberg AA, Husain MM, Trivedi MH, Fava M, Warden D, Wisniewski SR, Miyahara S, Rush AJ (2009) Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report. Psychol Med 22:1–10Google Scholar
  69. Nishino S (2007) The hypothalamic peptidergic system, hypocretin/orexin and vigilance control. Neuropeptides 41(3):117–133PubMedCrossRefGoogle Scholar
  70. Nofzinger EA (2008) Functional neuroimaging of sleep disorders. Curr Pharm Des 14(32):3417–3429PubMedCrossRefGoogle Scholar
  71. Nofzinger EA, Buysse DJ, Germain A, Price JC, Miewald JM, Kupfer DJ (2004) Functional neuroimaging evidence for hyperarousal in insomnia. Am J Psychiatry 161(11):2126–2128PubMedCrossRefGoogle Scholar
  72. Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardinali DP (2005) Melatonin and sleep in aging population. Exp Gerontol 40(12):911–925PubMedCrossRefGoogle Scholar
  73. Parry BL, Martinez LF, Maurer EL, Lopez AM, Sorenson D, Meliska CJ (2006) Sleep, rhythms and women’s mood. Part II. Menopause. Sleep Med Rev 10(3):197–208PubMedCrossRefGoogle Scholar
  74. Pavlova M, Berg O, Gleason R, Walker F, Roberts S, Regestein Q (2001) Self-reported hyperarousal traits among insomnia patients. J Psychosom Res 51(2):435–441PubMedCrossRefGoogle Scholar
  75. Perlis ML (1997) Psychophysiological insomnia: the behavioural model and a neurocognitive perspective. J Sleep Res 6:179–188PubMedCrossRefGoogle Scholar
  76. Perlis ML, Smith LJ, Lyness JM, Matteson SR, Pigeon WR, Jungquist CR, Tu X (2006) Insomnia as a risk factor for onset of depression in the elderly. Behav Sleep Med 4(2):104–113PubMedCrossRefGoogle Scholar
  77. Peyron C, Sapin E, Leger L, Luppi PH, Fort P (2009) Role of the melanin-concentrating hormone neuropeptide in sleep regulation. Peptides 30(11):2052–2059PubMedCrossRefGoogle Scholar
  78. Raymann RJEM, Van Someren EJW (2008) Diminished capability to recognize the optimal temperature for sleep initiation may contribute to poor sleep in elderly people. Sleep 31:1301–1309PubMedPubMedCentralGoogle Scholar
  79. Raymann RJEM, Swaab DF, Van Someren EJW (2008) Skin deep: cutaneous temperature determines sleep depth. Brain 131:500–513PubMedCrossRefGoogle Scholar
  80. Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system of sleep stages in human subjects. Brain Information Service/Brain Research Institute/University of California, Los AngelesGoogle Scholar
  81. Riemann D (2007) Insomnia and comorbid psychiatric disorders. Sleep Med 8(4):15–20CrossRefGoogle Scholar
  82. Riemersma-van der Lek R, Swaab DF, Twisk J, Hol EM, Hoogendijk WJG, Van Someren EJW (2008) Effect of bright light and melatonin on cognitive and non-cognitive function in elderly residents of group care facilities: a randomized controlled trial. J Am Med Assoc 299:2642–2655CrossRefGoogle Scholar
  83. Robertson JA, Broomfield NM, Espie CA (2007) Prospective comparison of subjective arousal during the pre-sleep period in primary sleep-onset insomnia and normal sleepers. J Sleep Res 16(2):230–238PubMedCrossRefGoogle Scholar
  84. Rosenwasser M (2009) Functional neuroanatomy of sleep and circadian rhythms. Brain Res Rev 61(2):281–306PubMedCrossRefGoogle Scholar
  85. Roth T (2005) An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia. Sleep Med 6:487–495PubMedCrossRefGoogle Scholar
  86. Salin-Pascual RJ, Roehrs TA, Merlotti LA, Zorick F, Roth T (1992) Long-term study of the sleep of insomnia patients with sleep state misperception and other insomnia patients. Am J Psychiatry 149(7):904–908PubMedCrossRefGoogle Scholar
  87. Saper CB (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437:1257–1263PubMedCrossRefGoogle Scholar
  88. Saper CB (2006) Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms, In: Kalsbeek A, Fliers E, Hofman MA, Swaab DF, van Someren EJW, Buijs RM (eds) Hypothalamic integration of energy metabolism, Progress in Brain Research, vol 153, pp 243–252Google Scholar
  89. Saper CB, Chou TC, Scammell TE (2001) The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 24(12):726–731PubMedCrossRefGoogle Scholar
  90. Sateia MJ, Doghramji K, Hauri PJ, Morin CM (2000) Evaluation of chronic insomnia. Sleep 23:243–308PubMedGoogle Scholar
  91. Scherder EJA, Van Someren EJW, Swaab DF (1999) Transcutaneous electrical nerve stimulation (TENS) improves the rest-activity rhythm in midstage Alzheimer’s disease. Behav Brain Res 101:105–107PubMedCrossRefGoogle Scholar
  92. Schulz P, Steimer T (2009) Neurobiology of circadian systems. CNS Drugs 23(2):3–13PubMedCrossRefGoogle Scholar
  93. Schutte-Rodin S, Broch L, Buysse D, Dorsey C and Sateia M (2008) Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med 4(5):487–504Google Scholar
  94. Spielman AJ, Glovinsky P (1991) The varied nature of insomnia. In: Hauri PJ (ed) Case studies in insomnia. Plenum, New YorkGoogle Scholar
  95. Steiger A (2006) Peptides and sleep. In: Kastin AJ (ed) Handbook of biologically active peptides. Academic, Burlington, pp 1521–1528CrossRefGoogle Scholar
  96. Stepanski EJ, Wyatt JK (2003) Use of sleep hygiene in the treatment of insomnia. Sleep Med Rev 7(3):215–225PubMedCrossRefGoogle Scholar
  97. Steriade M, Pare D, Bouhassira D, Deschenes M, Oakson G (1989) Phasic activation of lateral geniculate and perigeniculate thalamic neurons during sleep with ponto-geniculo-occipital waves. J Neurosci 9:2215–2229PubMedGoogle Scholar
  98. Taylor DJ, Mallory LJ (2007) Comorbidity of chronic insomnia with medical problems. Sleep 30:213–218PubMedGoogle Scholar
  99. Taylor DJ, Lichstein KL, Durrence HH, Reidel BW, Bush AJ (2005) Epidemiology of insomnia, depression, and anxiety. Sleep 28(11):1457–1464PubMedGoogle Scholar
  100. Todd Arnedt J (2006) Evaluation of insomnia patients. Sleep Med Clin 1:319–332CrossRefGoogle Scholar
  101. Van der Heijden KB, Smits MG, van Someren EJ, Gunning WB (2005) Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: a circadian rhythm sleep disorder. Chronobiol Int 22(3):559–570PubMedCrossRefGoogle Scholar
  102. Van Der Werf YD, Altena E, Schoonheim MM, Sanz-Arigita E, Vis JC, De Rijke W, Van Someren EJW (2009) Sleep benefits subsequent hippocampal functioning. Nat Neurosci 12:122–123CrossRefGoogle Scholar
  103. Van Der Werf YD, Altena E, Van Dijk KD, Strijers RLM, De Rijke W, Stam CJ, Van Someren EJW (2010) Is disturbed intracortical excitability a stable trait of chronic insomnia? A study using transcranial magnetic stimulation before and after multimodal sleep therapy. Biol Psychiatry 68:950–955PubMedCrossRefGoogle Scholar
  104. van Marken Lichtenbelt WD, Daanen HAM, Wouters L, Fronczek R, Raymann RJEM, Severens NMW, Van Someren EJW (2006) Evaluation of wireless determination of skin temperature using iButtons. Physiol Behav 88:489–497PubMedCrossRefGoogle Scholar
  105. Van Someren EJW (2004) Sleep propensity is modulated by circadian and behavior-induced changes in cutaneous temperature. J Therm Biol 29:437–444CrossRefGoogle Scholar
  106. Van Someren EJW (2007) Improving actigraphic sleep estimates: how many nights? J Sleep Res 16:269–275CrossRefGoogle Scholar
  107. Van Someren EJW, Nagtegaal E (2007) Improving melatonin circadian phase estimates. Sleep Med 8:590–601PubMedCrossRefGoogle Scholar
  108. Van Someren EJW, Van Gool WA, Vonk BFM, Mirmiran M, Speelman JD, Bosch DA, Swaab DF (1993) Ambulatory monitoring of tremor and other movements before and after thalamotomy: a new quantitative technique. J Neurol Sci 117:16–23PubMedCrossRefGoogle Scholar
  109. Van Someren EJW, Lijzenga C, Mirmiran M, Swaab DF (1997) Long-term fitness training improves the circadian rest-activity rhythm in healthy elderly males. J Biol Rhythms 12:146–156PubMedCrossRefGoogle Scholar
  110. Van Someren EJW, Scherder EJA, Swaab DF (1998) Transcutaneous electrical nerve stimulation (TENS) improves circadian rhythm disturbances in Alzheimer’s disease. Alzheimer Dis Assoc Disord 12:114–118PubMedCrossRefGoogle Scholar
  111. Van Someren EJW, Pollmächer T, Leger D, Espie C, Bassetti C, Riemann D (2009) The European insomnia network. Front Neurosci 3:436Google Scholar
  112. Vogel GW, Vogel F, McAbee RS, Thurmond AJ (1980) Improvement of depression by REM sleep deprivation new findings and a theory. Arch Gen Psychiatry 37(3):247–253PubMedCrossRefGoogle Scholar
  113. Walsh JK, Roehrs T, Roth T (2005) Pharmacologic treatment of primary insomnia. In: Kryger MH, Roth T, Dement WC (eds) Principles and practice of sleep medicine, 4th edn. Elsevier Saunders, Philadelphia, pp 749–760CrossRefGoogle Scholar
  114. Wilson S, Nutt D (2007) Treatment of insomnia. Psychiatry 6(7):301–304CrossRefGoogle Scholar
  115. World Health Organization (1993) The ICD-10 classification of mental and behavioural disorders, diagnostic criteria for research. World Health Organization, GenevaGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Sleep and CognitionNetherlands Institute for Neuroscience and VU University AmsterdamAmsterdamThe Netherlands
  2. 2.Vrije Universiteit BrusselBrusselsBelgium

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