Celiac Disease

  • Harold Chen
Living reference work entry


Celiac disease is a gastrointestinal disorder characterized by chronic inflammation of the small intestine that can develop in genetically susceptible individuals ingesting proteins in wheat (gliadin), rye (secalin), and barley (hordein), collectively called gluten. The prevalence of celiac disease in the United States and Canada is as high as 0.5–1 %, similar to earlier estimates outside North America (Hill et al. 2000).


Irritable Bowel Syndrome Celiac Disease Human Leukocyte Antigen Turner Syndrome Alopecia Areata 
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  1. Balaban, D. v., Popp, A., Vasilescu, F., et al. (2015). Diagnostic yield of endoscopic markers for celiac disease. Journal of Medicine and Life, 8, 452–457.PubMedCentralPubMedGoogle Scholar
  2. Calabrò, A., Gralka, E., Luchinat, C., et al. (2014). A metabolomics perspective on coeliac disease. Autoimmune Diseases, 204, 1–13.CrossRefGoogle Scholar
  3. Catassi, C., & Fasano, A. (2010). Celiac disease diagnosis: Simpler rules are better than complicated algorithms. American Journal of Medicine, 123, 691–693.Google Scholar
  4. Catassi, C., Ratsch, J. M., Fabiani, E., et al. (1994). Coeliac disease in the year 2000: Exploring the iceberg. Lancet, 343, 200–203.CrossRefPubMedGoogle Scholar
  5. Cranney, A., Zarkadas, M., Graham, I. D., et al. (2007). The Canadian celiac health survey. Digestive Diseases and Sciences, 52, 1087–1095.CrossRefPubMedGoogle Scholar
  6. Dieli-Crimi, R., Cénit, M. C., Núñez, C. (2015). The genetics of celiac disease: A comprehensive review of clinical implications. Journal of Autoimmunity, 64, 26–41.Google Scholar
  7. du Pré, M. F., & Sollid, L. M. (2015). T-cell and B-cell immunity in celiac disease. Best Practice & Research Clinical Gastroenterology, 29, 413–423.CrossRefGoogle Scholar
  8. Ediger, T. r., & Hill, I. D. (2014). Celiac disease. Pediatrics in Review, 55, 409–415.CrossRefGoogle Scholar
  9. Farrell, R. J., & Kelly, C. P. (2002). Celiac sprue. The New England Journal of Medicine, 346, 180–188.CrossRefPubMedGoogle Scholar
  10. Fasano, & Catassi. (2012). Celiac disease. New England Journal of Medicine, 367, 2419–2426.CrossRefPubMedGoogle Scholar
  11. Fersano, A., Berti, I., Gerarduzzi, T., et al. (2003). Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: A large multicenter study. Archives of Internal Medicine, 163, 286–292.CrossRefGoogle Scholar
  12. Green, P. H., Fleischauer, A. T., Bhagat, G., et al. (2003). Risk of malignancy in patients with celiac disease. The American Journal of Medicine, 115, 191–195.CrossRefPubMedGoogle Scholar
  13. Guandalini, S., & Assiri, A. (2014). Celiac disease. A review. JAMA Pediatrics, 168, 272–278.CrossRefPubMedGoogle Scholar
  14. Gudjónsdóttir, A. H., Nilsson, S., Ek, J., Kristiansson, B., & Ascher, H. (2004). The risk of celiac disease in 107 families with at least two affected siblings. Journal of Pediatric Gastroenterology and Nutrition, 38, 338–342.CrossRefPubMedGoogle Scholar
  15. Hill, I., Fasano, A., Schwartz, R., et al. (2000). The prevalence of celiac disease in at-risk groups of children in the United States. Journal of Pediatrics, 136, 86–90.CrossRefPubMedGoogle Scholar
  16. Hill, I. D., Dirks, M. H., Liptak, G. S., et al. (2005). Guideline for the diagnosis and treatment of celiac disease in children: Recommendations of the North American Society for pediatric gastroenterology, Hepatology and Nutrition. Journal of Pediatric Gastroenterology and Nutrition, 40, 1–19.CrossRefPubMedGoogle Scholar
  17. Holmes, G. K., Prior, P., Lane, M. R., et al. (1989). Malignancy in coeliac disease-effect of a gluten free diet. Gut, 30, 333–338.PubMedCentralCrossRefPubMedGoogle Scholar
  18. Kaukinen, K., Partanen, J., Maki, M., et al. (2002). HLA-DQ typing in the diagnosis of celiac disease. American Journal of Gastroenterology, 97, 695–699.CrossRefPubMedGoogle Scholar
  19. Koning, F. (2005). Celiac disease: Caught between a rock and a hard place. Gastroenterology, 129, 1294–1301.CrossRefPubMedGoogle Scholar
  20. Liu, E., Li, M., Emery, L., et al. (2007). Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease. Journal of Pediatric Gastroenterology and Nutrition, 45, 293–300.CrossRefPubMedGoogle Scholar
  21. Lundin, K. E. A., Scott, H., Fausa, O., et al. (1994). T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8. Human Immunology, 41, 285–291.CrossRefPubMedGoogle Scholar
  22. Mooney, P. D., Hadjivassiliou, M., & Sanders, D. S. (2014). Coeliac disease. BMJ, 348, 1–8.Google Scholar
  23. Niveloni, S., Sugai, E., Cabanne, A., et al. (2007). Antibodies against synthetic deamidated gliadin peptides as predictors of celiac disease: Prospective assessment in an adult population with a high pretest probability of disease. Clinical Chemistry, 53, 2186–2192.CrossRefPubMedGoogle Scholar
  24. Poon, E., & Nixon, R. (2001). Cutaneous spectrum of coeliac disease. Australian Journal of Dermatology, 42, 136–138.CrossRefGoogle Scholar
  25. Qiao, S. W., Bergseng, E., Molberg, O., et al. (2005). Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: Importance of proline spacing and glutamine deamidation. Journal of Immunology, 175, 254–261.CrossRefGoogle Scholar
  26. Rashid, M., Butzner, J. D., & Warren, R. (2009). Home blood testing for celiac disease. Recommendation for management. Canadian Family Physician, 55, 151–153.PubMedCentralPubMedGoogle Scholar
  27. Ravikumara, M., Tuthill, D. P., & Jenkins, H. R. (2006). The changing clinical presentation of coeliac disease. Archives of Disease in Childhood, 91, 969–971.PubMedCentralCrossRefPubMedGoogle Scholar
  28. Ricaño-Ponce, I., Wijmenga, C., & Gutierrez-Achury, J. (2015). Genetic of celiac disease. Best Practice & Research Clinical Gastroenterology, 19, 399–412.CrossRefGoogle Scholar
  29. Rodrigues, A. F., & Jenkins, H. R. (2008). Investigation and management of coeliac disease (review). Archives of Disease in Childhood, 93, 251–254.CrossRefPubMedGoogle Scholar
  30. Rostom, A., Murray, J. A., & Kagnoff, M. F. (2006). American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology, 131, 1981–2002.CrossRefPubMedGoogle Scholar
  31. Rubio-Tapia, A., Hill, I. D., Kelly, C. P., et al. (2013). ACG clinical guidelines; diagnosis and management of celiac disease. American Journal of Gastroenterology, 108, 656–676.PubMedCentralCrossRefPubMedGoogle Scholar
  32. Sapone, A., Bai, J. C., Ciacci, C., et al. (2012). Spectrum of gluten-related disorders: Consensus on new nomenclature and classification. BMC Medicine, 10, 13.Google Scholar
  33. Sollid, L. M. (2002). Coeliac disease: Dissecting a complex inflammatory disorder. Nature Reviews Immunology, 2, 647–655.CrossRefPubMedGoogle Scholar
  34. Sollid, L. M., & Khosla, C. (2005). Future therapeutic options for celiac disease. Nature Clinical Practice. Gastroenterology & Hepatology, 2, 140–147.CrossRefGoogle Scholar
  35. Sollid, L. M., & Lie, B. A. (2005). Celiac disease genetics: Current concepts and practical applications. Clinical Gastroenterology and Hepatology, 3, 843–851.CrossRefPubMedGoogle Scholar
  36. Taylor, A. K., Lebwohl, B., Snyder, C L., et al. (2015). Celiac disease. Gene Reviews. Updated 17 Sept 2015. Available at:
  37. Treem, W. R. (2004). Emerging concepts in celiac disease. Current Opinion in Pediatrics, 16, 552–559.CrossRefPubMedGoogle Scholar
  38. Verdu, E. E., Armstrong, D., & Murray, J. A. (2009). Between celiac disease and irritable bowel syndrome: The “no man’s land” of gluten sensitivity. American Journal of Gastroenterology, 104(6), 1587–1594.PubMedCentralCrossRefPubMedGoogle Scholar
  39. Westerberg, D. P., Gill, J. M., Dave, B., et al. (2006). New strategies for diagnosis and management of celiac disease. Journal of the American Osteopathic Association, 106, 145–151.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Medical GeneticsShriners Hospitals for ChildrenShreveportUSA
  2. 2.Perinatal and Clinical Genetics, Department of PediatricsLSU Health Sciences CenterShreveportUSA

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