Vasculitis, inflammation of the vessel wall, can result in mural destruction with hemorrhage, aneurysm formation, and infarction, or intimal-medial hyperplasia and subsequent stenosis leading to tissue ischemia and infarction. The skin, in part due to its large vascular bed, exposure to cold temperatures, and frequent presence of stasis, is involved in many distinct as well as unnamed vasculitic syndromes that vary from localized and self-limited to generalized and life-threatening with multi-organ disease. Cutaneous vasculitis comprises a wide spectrum of overlapping primary and secondary disease entities that are characterized by predominant skin involvement and varying degrees of systemic manifestations (Carlson et al. 2005).
KeywordsKawasaki Disease Giant Cell Arteritis Takayasu Arteritis Hairy Cell Leukemia Mixed Connective Tissue Disease
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