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Mobile Metagenome

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Encyclopedia of Metagenomics
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Synonyms

Gut microbiota; Lateral gene transfer; Mobile microbiome; Phage

Definitions

Metagenome: The collective genomes of all members of a bacterial community.

Mobile metagenome: The total pool of mobile genetic elements associated with a bacterial community.

Mobile genetic element (MGE): A discrete genetic unit capable of mediating its own transfer between distinct DNA molecules, and/or between distinct host cells of the same or different species. Plasmids, transposons, insertion sequences, conjugative transposons, integrons, and bacteriophage are all examples of MGE.

Horizontal gene transfer: Transfer and acquisition of genetic material between distinct cells or species, outside of and in addition to the normal process of inheritance (vertical gene transfer).

Introduction

The adult human gastrointestinal tract (GIT) is home to a dense population of microorganisms, reaching an estimated 1013–1014individual prokaryotic cells in the distal colon and dominated by bacteria from ~150 to...

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References

  • Breitbart M, Hewson I, Felts B, et al. Metagenomic analyses of an uncultured viral community from human feces. J Bacteriol. 2003;185:6220–3.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Caporaso JG, Knight R, Kelley ST. Host-associated and free-living phage communities differ profoundly in phylogenetic composition. PLoS ONE. 2011;6:e16900.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Claesson MJ, Li Y, Leahy S, et al. Multireplicon genome architecture of Lactobacillus salivarius. Proc Natl Acad Sci U S A. 2006;103:6718–23.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Corr SC, Li Y, Riedel CU, et al. Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. Proc Natl Acad Sci U S A. 2007;104:7617–21.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Croxen MA, Finlay BB. Molecular mechanisms of Escherichia coli pathogenicity. Nat Rev Microbiol. 2010;8:26–38.

    CAS  PubMed  Google Scholar 

  • Ebdon J, Muniesa M, Taylor H. The application of a recently isolated strain of Bacteroides (GB-124) to identify human sources of faecal pollution in a temperate river catchment. Water Res. 2007;41:3683–90.

    Article  CAS  PubMed  Google Scholar 

  • Hehemann J-H, Correc G, Barbeyon T, et al. Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature. 2010;464:908–12.

    Article  CAS  PubMed  Google Scholar 

  • Jones BV. The human gut mobile metagenome: a metazoan perspective. Gut Microbes. 2010;1(6):417–33.

    Article  Google Scholar 

  • Jones BV, Marchesi JR. Accessing the mobile metagenome of the human gut microbiota. Mol Biosyst. 2007;3:749–58.

    Article  CAS  PubMed  Google Scholar 

  • Jones BV, Sun F, Marchesi JR. Comparative metagenomic analysis of plasmid encoded functions in the human gut microbiome. BMC Genomics. 2010;11:46.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kurokawa K, Itoh T, Kuwahara T, Oshima K, Toh H, Toyoda A, et al. Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes. DNA Res. 2007;14:169–81.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lepage P, Colombet J, Marteau P, et al. Dysbiosis in inflammatory bowel disease: a role for bacteriophages? Gut. 2008;57:424–5.

    Article  CAS  PubMed  Google Scholar 

  • Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell. 2006;124:837–48.

    Article  CAS  PubMed  Google Scholar 

  • Licht TN, Wilcks A. Conjugative gene transfer in the gastrointestinal environment. Adv Appl Microbiol. 2005;58:77–95.

    Article  Google Scholar 

  • Lozupone CA, Hamady M, Cantral BL, et al. The convergence of carbohydrate active gene repertoires in human gut microbes. Proc Natl Acad Sci U S A. 2008;105:15076–81.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • McNiel NI. The contribution of the large intestine to energy supplies in man. Am J Clin Nutr. 1984;39:338–42.

    Google Scholar 

  • Ochman H, Lawrence JG, Groisman EA. Lateral gene transfer and the nature of bacterial innovation. Nature. 2000;405:299–304.

    Article  CAS  PubMed  Google Scholar 

  • Ogilvie LA, Firouzmand S, Jones BV. Evolutionary, ecological and biotechnological perspectives on plasmids resident in the human gut mobile metagenome. Bioeng Bugs. 2012a;3(1):1–19.

    Article  Google Scholar 

  • Ogilvie LA, Caplin J, Dedi C, et al. Comparative (meta)genomic analysis and ecological profiling of human gut-specific bacteriophage ɸ B124-14. PLoS ONE. 2012b;7:e35053.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59–65.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Reyes A, Haynes M, Hanson N, et al. Viruses in the faecal microbiota of monozygotic twins and their mothers. Nature. 2010;466:334–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Salyers AA, Gupta A, Wang YP. Human intestinal bacteria as reservoirs for antibiotic resistance genes. Trends Microbiol. 2004;12:412–6.

    Article  CAS  PubMed  Google Scholar 

  • Smalla K, Osburne AM, Wellington EMH. Isolation and characterisation of plasmids from bacteria. In: CM Thomas (ed) The horizontal gene pool, bacterial plasmids and gene spread. Amsterdam: Harwood Academic Publishers; 2000. p. 207–48.

    Google Scholar 

  • Smilie CD, Smith MB, Friedman J, et al. Ecology drives a global network of gene exchange connecting the human microbiome. Nature. 2011. doi:10.1038/nature10571.

    Google Scholar 

  • Sommer MOA, Dantas G, Church GM. Functional characterisation of the antibiotic resistance reservoir in the human microflora. Science. 2009;325:1128–31.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Brian V. Jones .

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© 2012 Springer Science+Business Media New York

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Jones, B.V. (2012). Mobile Metagenome. In: Nelson, K. (eds) Encyclopedia of Metagenomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6418-1_97-3

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  • DOI: https://doi.org/10.1007/978-1-4614-6418-1_97-3

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