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Genome Atlases, Potential Applications in Study of Metagenomes

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Encyclopedia of Metagenomics

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Traditional microbiology has used a single species approach, as in Koch’s postulates, where a bacterium is shown to be pathogenic by first isolation from infected organisms, then grown in monoculture, and finally reintroduced into healthy individuals and causing the disease. In contrast, microbial ecology studies multispecies and community structures. Both of these areas have been very successful, and these two different approaches can be seen in comparative genomics, with the traditional analysis of single genomes versus many genomes or metagenomes isolated from an environment. It is possible to relate microbial ecology to reductionist, monoculture microbiology by comparing the two different data types. In this case, the reference is the single genome of an organism, the other being the metagenome samples where most of the DNA in the environment is sampled. Surely, the comparisons are most reliable when the environmental DNA is preferably in chunks containing at least several genes –...

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Authors and Affiliations

  1. The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark

    Asli Ismihan Ozen

  2. Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Søltofts Plads Building 221, room 002, 2800, Kongens Lyngby, Denmark

    David Wayne Ussery

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  1. Asli Ismihan Ozen
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  2. David Wayne Ussery
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Correspondence to Asli Ismihan Ozen .

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Editors and Affiliations

  1. J. Craig Venter Institute (JCVI), Rockville, Maryland, USA

    Karen E. Nelson

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Ozen, A.I., Ussery, D.W. (2013). Genome Atlases, Potential Applications in Study of Metagenomes. In: Nelson, K. (eds) Encyclopedia of Metagenomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6418-1_686-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6418-1_686-1

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