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Role of Microorganisms in Oral and Oropharyngeal Squamous Cell Carcinoma

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Encyclopedia of Metagenomics

Introduction and Epidemiology

Oral and oropharyngeal squamous cell carcinoma (OSCC) is a heterogeneous group of malignancies that is documented worldwide due in part to the common use of tobacco and alcohol. Globally, approximately 400,000 cases are diagnosed annually with a mortality rate of over 223,000 (Ferlay et al. 2010). Furthermore, this group of head and neck cancers ranks among the top ten most common malignancies worldwide (Ferlay et al. 2010). According to 2012 US statistics, an estimated 40,000 new cancers of the oral cavity and pharynx will be diagnosed, and over 90 % of the cases will be SCC (Siegel et al. 2012). These cancers are estimated to represent over 2% of all malignancies in 2012, and approximately 7,850 individuals will die of this disease (Siegel et al. 2012). Of importance, there are significant changes in the incidence of OSCC depending upon the location. Alarming annual increases of 5% are observed in the oropharynx, in contrast to a decrease in oral cavity...

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Authors and Affiliations

  1. Diagnostic Sciences, College of Dental Medicine, Georgia Regents University, 1430 John Wesley Gilbert Dr., GC2250, Augusta, GA, 30912, USA

    Zoya B. Kurago

  2. Faculty of Dentistry, Department of Oral Diagnosis, Srinakharinwirot University, 114 Sukhumvit 23, 10110, Bangkok, Thailand

    Aroonwan Lam-ubol

  3. Oral & Maxillofacial Pathology, Department of Diagnostic and Biomedical Sciences, The University of Texas School of Dentistry at Houston, 7500 Cambridge St., Rm 5357, Houston, TX, 77054, USA

    Catherine M. Flaitz

Authors
  1. Zoya B. Kurago
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  2. Aroonwan Lam-ubol
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  3. Catherine M. Flaitz
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Corresponding author

Correspondence to Zoya B. Kurago .

Editor information

Editors and Affiliations

  1. J. Craig Venter Institute (JCVI), Rockville, Maryland, USA

    Karen E. Nelson

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Kurago, Z.B., Lam-ubol, A., Flaitz, C.M. (2013). Role of Microorganisms in Oral and Oropharyngeal Squamous Cell Carcinoma. In: Nelson, K. (eds) Encyclopedia of Metagenomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6418-1_61-11

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  • DOI: https://doi.org/10.1007/978-1-4614-6418-1_61-11

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  • Online ISBN: 978-1-4614-6418-1

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