Skip to main content
SpringerLink
Log in

Complex Sputum Microbial Composition in Patients with Pulmonary Tuberculosis

  • Living reference work entry
  • First Online:
Encyclopedia of Metagenomics

  • 150 Accesses

Synonyms

Sputum microbiome in patients with pulmonary tuberculosis

Definitions

Pulmonary tuberculosis patients: the patients were clinically diagnosed with pulmonary tuberculosis based on sputum smear, sputum culture, and computed tomography results. All patients were free of HIV. None of the patients had taken antibiotics for at least 3 months before sampling.

Healthy participants: the participants were free of basic pulmonary diseases, severe lung disease, severe oral disease, systemic disease, and other known diseases such as obesity or diabetes, which could affect the microbial composition of the respiratory tract. Volunteers with a history of smoking or drinking were also excluded. The healthy participants had not taken any antibiotics for at least 3 months before sampling. The samples from healthy participants were a mixture of saliva and pharyngeal secretions collected by deep coughing in the early morning before gargling.

Microbiota: the bacterial composition.

Introduction

Chron...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Ardies CM. Inflammation as cause for scar cancers of the lung. Integr Cancer Ther. 2003;2(3):238–46.

    Article  PubMed  Google Scholar 

  • Blaser MJ, Falkow S. What are the consequences of the disappearing human microbiota? Nat Rev Microbiol. 2009;7(12):887–94.

    Article  CAS  PubMed  Google Scholar 

  • Chakravorty S, Helb D, Burday M, Connell N, Alland D. A detailed analysis of 16S ribosomal RNA gene segments for the diagnosis of pathogenic bacteria. J Microbiol Methods. 2007;69(2):330–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Charlson ES, Bittinger K, Haas AR, Fitzgerald AS, Frank I, Yadav A, Bushman FD, Collman RG. Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med. 2011;184(8):957–63.

    Article  PubMed Central  PubMed  Google Scholar 

  • Chuvochina MS, Marie D, Chevaillier S, Petit JR, Normand P, Alekhina IA, Bulat SA. Community variability of bacteria in alpine snow (Mont Blanc) containing Saharan dust deposition and their snow colonisation potential. Microbes Environ. 2011;26(3):237–47.

    Article  PubMed  Google Scholar 

  • Coenye T, Goris J, Spilker T, Vandamme P, LiPuma JJ. Characterization of unusual bacteria isolated from respiratory secretions of cystic fibrosis patients and description of Inquilinus limosus gen. nov., sp. nov. J Clin Microbiol. 2002;40(6):2062–9.

    Article  PubMed Central  PubMed  Google Scholar 

  • Cui Z, Zhou Y, Li H, Zhang Y, Zhang S, Tang S, Guo X. Complex sputum microbial composition in patients with pulmonary tuberculosis. BMC Microbiol. 2012;12(1):276.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Delhaes L, Monchy S, Frealle E, Hubans C, Salleron J, Leroy S, Prevotat A, Wallet F, Wallaert B, Dei-Cas E, et al. The airway microbiota in cystic fibrosis: a complex fungal and bacterial community–implications for therapeutic management. PLoS ONE. 2012;7(4):e36313.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Fishman JA. Infections in immunocompromised hosts and organ transplant recipients: essentials. Liver Transpl. 2011;17 Suppl 3:S34–7.

    Article  PubMed  Google Scholar 

  • Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL, Erb-Downward J, Lynch SV, Sethi S, et al. Significance of the microbiome in obstructive lung disease. Thorax. 2012;67(5):456–63.

    Article  PubMed Central  PubMed  Google Scholar 

  • Huang YJ, Lynch SV. The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications. Expert Rev Respir Med. 2011;5(6):809–21.

    Article  PubMed Central  PubMed  Google Scholar 

  • Huang HY, Tsai YS, Lee JJ, Chiang MC, Chen YH, Chiang CY, Lin NT, Tsai PJ. Mixed infection with Beijing and non-Beijing strains and drug resistance pattern of Mycobacterium tuberculosis. J Clin Microbiol. 2010;48(12):4474–80.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Khan Z, Miller A, Bachan M, Donath J. Mycobacterium Avium Complex (MAC) lung disease in two inner city community hospitals: recognition, prevalence, co-infection with Mycobacterium Tuberculosis (MTB) and Pulmonary Function (PF) improvements after treatment. Open Respir Med J. 2010;4:76–81.

    Article  PubMed Central  PubMed  Google Scholar 

  • Robinson CJ, Bohannan BJ, Young VB. From structure to function: the ecology of host-associated microbial communities. Microbiol Mol Biol Rev. 2010;74(3):453–76.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ryan MP, Adley CC. Sphingomonas paucimobilis: a persistent Gram-negative nosocomial infectious organism. J Hosp Infect. 2010;75(3):153–7.

    Article  CAS  PubMed  Google Scholar 

  • Sansonetti PJ. To be or not to be a pathogen: that is the mucosally relevant question. Mucosal Immunol. 2011;4(1):8–14.

    Article  CAS  PubMed  Google Scholar 

  • Staley JT, Konopka A. Measurement of in situ activities of nonphotosynthetic microorganisms in aquatic and terrestrial habitats. Annu Rev Microbiol. 1985;39:321–46.

    Article  CAS  PubMed  Google Scholar 

  • Young D, Stark J, Kirschner D. Systems biology of persistent infection: tuberculosis as a case study. Nat Rev Microbiol. 2008;6(7):520–8.

    Article  CAS  PubMed  Google Scholar 

  • Zhou Y, Lin P, Li Q, Han L, Zheng H, Wei Y, Cui Z, Ni Y, Guo X. Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections. Acta Biochim Biophys Sin (Shanghai). 2010;42(10):754–61.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Laboratory Medicine, Shanghai First People’s Hospital, Medical College, Shanghai Jiaotong University, 200080, Shanghai, China

    Zelin Cui

Authors
  1. Zelin Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zelin Cui .

Editor information

Editors and Affiliations

  1. J. Craig Venter Institute (JCVI), Rockville, Maryland, USA

    Karen E. Nelson

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this entry

Cite this entry

Cui, Z. (2013). Complex Sputum Microbial Composition in Patients with Pulmonary Tuberculosis. In: Nelson, K. (eds) Encyclopedia of Metagenomics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6418-1_389-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6418-1_389-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6418-1

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation