Living Reference Work Entry

Encyclopedia of Metagenomics

pp 1-15

Date: Latest Version

New Method for Comparative Functional Genomics and Metagenomics Using KEGG MODULE

  • Hideto TakamiAffiliated withMicrobial Genome Research Group, Japan Agency for Marine-Earth Science and Technology (JAMSTEC) Email author 


Functional potential evaluator


Although one of the main goals of genomic analysis is to elucidate the comprehensive functions (functionome) in individual organisms or a whole community in various environments, a standard evaluation method for discerning the functional potentials harbored within the genome or metagenome has not yet been established. Thus, a new evaluation method for the potential functionome, based on the completion ratio of Kyoto Encyclopedia of Genes and Genomes (KEGG) functional modules, was developed. Basic methodology and application of this method for comparative functional genomics and metagenomics are expounded in this entry.


One of the main goals of genomic and metagenomic analyses is to extract the comprehensive functions (functionome) harbored in an individual organism or a whole community in various environments. However, evaluating the potential functionome is still difficult when compared with the functional annotation of indivi ...

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