Encyclopedia of Metagenomics

Living Edition
| Editors: Karen E. Nelson

Human Oral Microbiome Database (HOMD)

  • Tsute Chen
  • Floyd Dewhirst
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6418-1_13-5

Introduction

The human oral cavity is a rich biological site with several microbial niches including teeth, gingival sulcus, tongue, cheek, hard and soft palates, tonsils, throat, and saliva. The microbiome of the oral cavity (Dewhirst et al. 2010) and its niches have been examined based on 16S rRNA sequencing (Aas et al. 2005; Bik et al. 2010; Human Microbiome Project 2012). The metagenome of the oral cavity has been studied to a limited degree prior to 2012 due to the complexity of the site (Alcaraz et al. 2012; Belda-Ferre et al. 2012; Xie et al. 2010). More than 700 prevalent species comprise the oral microbiome, but many taxa are present at less than 0.1 % of the microbial population (Dewhirst et al. 2010). As oral bacterial reference genomes are becoming available, primarily through the efforts of the Human Microbiome Project (Human Microbiome Project 2012), it is becoming possible to attribute metagenomic sequences to organisms at genus and species level (Martin et al. 2012)....

Keywords

Query Sequence Human Microbiome Project NCBI Taxonomy Genome Viewer Subject Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of MicrobiologyThe Forsyth InstituteCambridgeUSA
  2. 2.Department of Molecular GeneticsThe Forsyth InstituteCambridgeUSA