Synonyms
Cell attachment; Cell binding; Cell capture; Cell release
Definition
Cell adhesion results from specific attractive interactions between molecules on the cell surface and a substrate, which may be coated with more than one kind of molecule. Cell detachment represents the termination of these interactions by physical, chemical, electrical, optical, or other means.
Overview
Cells adhere to surfaces when attractive forces exist between the cell surface and the substrate of interest. In vivo, cells in animal tissues adhere to the extracellular matrix, by binding of adhesion receptors in the cell’s membrane to the proteins of the extracellular matrix. Extracellular matrix is an interdigitating network of proteins and polysaccharides secreted by the cells themselves. For successful cultivation of anchorage dependent cells in a microfluidic device, it is necessary to provide means for the cells to attach to the device surface. Some surfaces, such as glass or poly(methyl methacrylate)...
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Murthy, S.K., Radisic, M. (2015). Cell Adhesion and Detachment. In: Li, D. (eds) Encyclopedia of Microfluidics and Nanofluidics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5491-5_177
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DOI: https://doi.org/10.1007/978-1-4614-5491-5_177
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Publisher Name: Springer, New York, NY
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Online ISBN: 978-1-4614-5491-5
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