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Molecular Bacteriology and Mycobacteriology

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Molecular Genetic Pathology

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Abstract

Molecular diagnosis was first introduced to clinical microbiology in the late 1980s. Since then, the molecular technologies have improved significantly and molecular tests have become a very important part of clinical microbiology services for identification, quantification, and speciation of microorganisms. In this chapter, the authors summarize and comment on the state-of-the-art molecular methods for the diagnosis of infectious diseases caused by important bacterial and mycobacterial pathogens. For the molecular methods commonly used in clinical laboratories, we outline the principles and characteristics as well as the commercially available instruments and reagents. For each bacterial pathogen, we describe the general etiologic characteristics and clinical presentation and contrast the pearls and pitfalls of detection platforms currently available in clinical microbiology practice. For detailed methodology discussion, please refer to method chapter.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Inje University College of Medicine, Busanjin-gu, Busan, South Korea

    Jeong Hwan Shin MD, PhD

  2. Molecular Pathology Laboratory, Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA

    Mona Sharaan MD

  3. Mount Sinai School of Medicine, New York, NY, USA

    Josephine Wu DDS, CLSP(MB), CLDIR (Assistant Professor of Pathology)

  4. Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA

    Miao Cui MD (Associate Researcher of Pathology) & David Y. Zhang MD, PhD, MPH (Professor of Pathology, Director of Molecular Pathology Laboratory)

  5. Memorial Sloan-Kettering Cancer Center, Professor of Laboratory Medicine and Pathology, Cornell University Weil College of Medicine, New York, NY, USA

    Yi-Wei Tang MD, PhD, F(AAM), FIDSA (Associate Professor, Chief of Clinical Microbiology Service)

Authors
  1. Jeong Hwan Shin MD, PhD
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  2. Mona Sharaan MD
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  3. Josephine Wu DDS, CLSP(MB), CLDIR
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  4. Miao Cui MD
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  5. David Y. Zhang MD, PhD, MPH
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  6. Yi-Wei Tang MD, PhD, F(AAM), FIDSA
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Editor information

Editors and Affiliations

  1. School of Medicine, Dept. Pathology, Indiana University, N. University Blvd. 550, Indianapolis, 46202, Indiana, USA

    Liang Cheng

  2. Dept. Pathology, Mount Sinai School of Medicine, Gustave L. Levy Place 1, New York, 10029, New York, USA

    David Y. Zhang

  3. School of Medicine, Department of Pathology and, Indiana University, 635 Barnhill Drive, Indianapolis, 46202, Indiana, USA

    John N. Eble

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Shin, J.H., Sharaan, M., Wu, J., Cui, M., Zhang, D.Y., Tang, YW. (2013). Molecular Bacteriology and Mycobacteriology. In: Cheng, L., Zhang, D., Eble, J. (eds) Molecular Genetic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4800-6_26

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  • DOI: https://doi.org/10.1007/978-1-4614-4800-6_26

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  • Print ISBN: 978-1-4614-4799-3

  • Online ISBN: 978-1-4614-4800-6

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