Melatonin Use in Autism Spectrum Disorders
Melatonin is a neurohormone secreted by the pineal gland. It is synthesized from the amino acid tryptophan and undergoes catabolism in the body. These children commonly have disturbances with their sleep, with the most common being insomnia. Melatonin has been used quite effectively in this subgroup of children; however, optimal dosing is still not clear.
KeywordsFatigue Depression Adenosine Serotonin Retina
- Malow B, Adkins KW, McGrew SG, et al. Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. J Autism Dev Disord. 2012;42:1729–37.Google Scholar