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Optogenetic Implants

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Handbook of Biochips

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Abstract

Using optogenetics for neuromodulation demonstrates a high potential, and it may become a useful tool to analyze complicated neural circuits and provide an effective gene therapy for chronic brain illnesses. One of the key challenges is to develop a miniaturized, intelligent, integrated, multi-site/multilayer, multimodal optogenetic implant. This chapter first introduces the optogenetics and its typical biomedical applications. Then this chapter gives an overview of the recent advance in the technology developments in optogenetic implants. Both discrete optogenetic implants and integrated optogenetic implants are described. Particularly, a microchip-based integrated approach (HUBIN optrode) demonstrated a possibility toward the development of new-generation intelligent, integrated, miniaturized, multimodal optogenetic implants.

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Authors and Affiliations

  1. Department of Medical Physics and Biomedical Engineering, University College London, London, UK

    Hubin Zhao

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  1. Hubin Zhao
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Correspondence to Hubin Zhao .

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Editors and Affiliations

  1. Cutting-edge Net of Biomedical Research And INnovation (CenBRAIN) School of Engineering, Westlake University, Hangzhou, Zhejiang, China

    Mohamad Sawan

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Zhao, H. (2022). Optogenetic Implants. In: Sawan, M. (eds) Handbook of Biochips. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3447-4_48

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