Anorexia Nervosa and Bulimia

Reference work entry

Abstract

Eating disorders, including anorexia nervosa and bulimia nervosa, have long been recognized in psychiatry and other medical disciplines for their primary dysregulation in the basic ability to eat and inability to maintain weight without significant distress or dysregulation. Although the diagnostic criteria of these disorders have been debated over time, the core feature remain as (1) disturbances in the ability to maintain a healthy weight, (2) recurrent binge-eating or compensatory behavior, and (3) significant disturbances in the investment and perceptions of shape, weight, or appearance. The neurobiology of these disorders has been aided greatly by the study of eating behavior and weight regulation designed to study obesity. This chapter summarizes the current state of knowledge about the genetic, hormonal, neurotransmitter, and functional neurocircuitry of these disorders. Emerging evidence suggests that appetite hormones and peptides, adrenal hormones, ovarian hormones, and serotonin and dopamine are dysregulated in both disorders. Despite these advances, no neurobiological model has been able to explain the differences in prevalence rates between men and women or the common occurrence of expression during puberty. It is likely that relevant hormonal systems and neurotransmitter changes are working synergistically to affect these disorders. Future directions in translational and clinical research are discussed.

Keywords

Obesity Estrogen Dopamine Cortisol Schizophrenia 

Further Reading

  1. Bailer UF, Frank GK, Henry SE, Price JC, Meltzer CC, Mathis CA et al (2007) Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa. Biol Psychiatry 61:1090–1099PubMedCrossRefGoogle Scholar
  2. Helder SG, Collier DA (2011) The genetics of eating disorders. Curr Top Behav Neurosci 6:157–175PubMedCrossRefGoogle Scholar
  3. Hildebrandt T, Alfano L, Tricamo M, Pfaff DW (2010) Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa. Clin Psychol Rev 30:655–668PubMedCrossRefGoogle Scholar
  4. Kaye W (2008) Neurobiology of anorexia and bulimia nervosa. Physiol Behav 94:121–135PubMedCrossRefGoogle Scholar
  5. Klump KL, Bulik CM, Kaye WH, Treasure J, Tyson E (2009) Academy for eating disorders position paper: eating disorders are serious mental illnesses. Int J Eat Disord 42:97–103PubMedCrossRefGoogle Scholar
  6. Klump KL, Keel PK, Sisk C, Burt SA (2010) Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychol Med 40:1745–1753PubMedCrossRefGoogle Scholar
  7. Mathes WF, Brownley KA, Mo X, Bulik CM (2009) The biology of binge eating. Appetite 52:545–553PubMedCrossRefGoogle Scholar
  8. Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS et al (2010) Association study of 182 candidate genes in anorexia nervosa. Am J Med Genet B Neuropsychiatr Genet 153B:1070–1080PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.PsychiatryMount Sinai School of MedicineNew YorkUSA

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