Skip to main content
SpringerLink
Log in

The Neurobiology of Bipolar Disorder

  • Reference work entry
Neuroscience in the 21st Century

  • 915 Accesses

Abstract

When you’re high, it’s tremendous. The ideas and feelings are fast and frequent like shooting stars, and you follow them until you find better and brighter ones. Shyness goes, the right words and gestures are suddenly there, and the power to seduce and captivate others is a felt certainty. There are interests found in uninteresting people. Sensuality is pervasive and the desire to seduce and be seduced irresistible. Feelings of ease, intensity, power, well-being, financial omnipotence, and euphoria now pervade one’s marrow. But somehow this changes: the fast ideas are far too fast, and there are far too many; overwhelming confusion replaces clarity. Memory goes. You are irritable, angry, frightened, uncontrollable, and enmeshed totally in the blackest caves of the mind. (K. Jamieson)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 1,699.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Further Reading

  • Andreazza AC et al (2009) 3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder. J Psychiatry Neurosci 34:263–271

    PubMed  Google Scholar 

  • Goodwin FK, Jamison KR (2007) Neurobiology. In: Manic-depressive illness: the bipolar disorders and recurrent depression, 2nd edn. Oxford University Press, New York, pp 463–607

    Google Scholar 

  • Langan C, McDonald C (2009) Neurobiological trait abnormalities in bipolar disorder. Mol Psychiatry 14(9):833–846

    Article  PubMed  CAS  Google Scholar 

  • Levinson AJ et al (2007) Cortical inhibitory dysfunction in bipolar disorder: a study using transcranial magnetic stimulation. J Clin Psychopharmacol 27(5):493–497

    Article  PubMed  Google Scholar 

  • Post RM, Rubinow DR, Ballanger JC (1984) In: Post RM, Ballenger JC (eds) Conditioning, sensitization, and kindling: implications for the course of Affective Illness. Lippincott, Baltimore

    Google Scholar 

  • Schultze TG (2010) Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization. Psychiatr Clin North Am 33(1):67–82

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Psychiatry and Pharmacology, Centre for Addiction & Mental Health – Clarke Site, 250 College Street, Toronto, ON, M5T 1R8, Canada

    Dr. Andrea Levinson & Prof. Trevor Young

Authors
  1. Dr. Andrea Levinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Trevor Young
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY, USA

    Donald W. Pfaff

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media, LLC

About this entry

Cite this entry

Levinson, A., Young, T. (2013). The Neurobiology of Bipolar Disorder. In: Pfaff, D.W. (eds) Neuroscience in the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1997-6_117

Download citation

Publish with us

Policies and ethics

Search

Navigation