Names and (Some) Synonyms
Catechol oxidase (CO), EC 1.10.3.1, 1,2-Benzenediol:oxygen oxidoreductase, Diphenoloxidase, o-Diphenolase, Catecholase
Tyrosinase (Ty), EC 1.14.18.1, Monophenol, L-dopa:dioxygen oxidoreductase, Monophenol monooxygenase, Monophenol oxidase, Cresolase
General Description and Properties
Catechol oxidase (CO) and tyrosinase (Ty) are oxidoreductases (EC1) that possess active sites with two copper atoms (type 3 copper centers). Reports on these enzymes’ molecular weights are diverse and variable. Tertiary and quaternary structures of CO and Ty also display considerable variability in amino acid sequences. However, significant sequence homology between the active site regions is observed. The copper ions are surrounded by three nitrogen donor atoms from histidine residues. Ty and CO have been identified in three distinct forms in various stages of the catalytic cycle: a native met state (CuII-CuII), a reduced deoxy state (CuI CuI), and an oxystate with a dioxygen...
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Belle, C. (2013). Catechol Oxidase and Tyrosinase. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_98
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DOI: https://doi.org/10.1007/978-1-4614-1533-6_98
Publisher Name: Springer, New York, NY
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