Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Catechol Oxidase and Tyrosinase

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_98

Names and (Some) Synonyms

Catechol oxidase (CO), EC 1.10.3.1, 1,2-Benzenediol:oxygen oxidoreductase, Diphenoloxidase, o-Diphenolase, Catecholase

Tyrosinase (Ty), EC 1.14.18.1, Monophenol, L-dopa:dioxygen oxidoreductase, Monophenol monooxygenase, Monophenol oxidase, Cresolase

General Description and Properties

Catechol oxidase (CO) and tyrosinase (Ty) are oxidoreductases (EC1) that possess active sites with two copper atoms (type 3 copper centers). Reports on these enzymes’ molecular weights are diverse and variable. Tertiary and quaternary structures of CO and Ty also display considerable variability in amino acid sequences. However, significant sequence homology between the active site regions is observed. The copper ions are surrounded by three nitrogen donor atoms from histidine residues. Ty and CO have been identified in three distinct forms in various stages of the catalytic cycle: a native met state (Cu II-Cu II), a reduced deoxy state (Cu I Cu I), and an oxystate with a dioxygen...
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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Département de Chimie Moléculaire, UMR-CNRS 5250Université Joseph Fourier, ICMG FR-2607GrenobleFrance