Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Copper, Mononuclear Monooxygenases

  • Marius Réglier
  • Catherine Belle
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_97



Copper mononuclear monooxygenase is a unique class of metalloenzymes present in eukaryotes where they catalyze very important biosynthetic reactions in neurotransmitter and hormone pathways. Composed by dopamine β-monooxygenase (DβM), also named dopamine β-hydroxylase (DβH), tyramine β-monooxygenase (TβM), peptidylglycine α-hydroxylating monooxygenase (PHM), and monooxygenase X (MOX), this class of metalloenzymes is characterized by the presence of two independent T2  Cu-Binding Sites where only one copper atom is involved in the hydroxylation reaction.

General Background

Mononuclear copper monooxygenases catalyze the stereospecific oxygen atom insertion in organic substrates and are ascorbate (reducer) and dioxygen-dependents (Klinman 1996).

Dopamine β-monooxygenase (DβM, EC is a mammalian enzyme involved in the catecholamine biosynthetic pathway where it transforms dopamine into...
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Faculté des Sciences et Techniques, ISM2/BiosCiences UMR CNRS 7313Aix-Marseille Université Campus Scientifique de Saint JérômeMarseilleFrance
  2. 2.Département de Chimie MoléculaireUMR-CNRS 5250, Université Joseph Fourier, ICMG FR-2607GrenobleFrance