Cytochrome c Oxidase, CuA Center
CuA is a binuclear, mixed-valent [Cu(1.5+)-Cu(1.5+)], spin S = 1/2 electron transfer center present in respiratory chains of numerous organisms, specifically in cytochrome c oxidase (CcO) which reduces O2 to two molecules of H2O and nitrous oxide (N2O) reductase (N2OR) which reduces N2O to N2 and H2O. The core structure of CuA consists of a Cu2S2 rhomb with unique spectroscopic features, specifically the seven-line electron paramagnetic resonance spectrum observed at low temperatures.
Structure and Function of CuA
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